List of works - Karen A Fortner

Activation of gamma delta T cells by Borrelia burgdorferi is indirect via a TLR- and caspase-dependent pathway

scientific article

Activation of the p38 mitogen-activated protein kinase pathway arrests cell cycle progression and differentiation of immature thymocytes in vivo

scientific article

Apoptosis regulators Fas and Bim cooperate in shutdown of chronic immune responses and prevention of autoimmunity

scientific article published on February 2008

Apoptosis regulators Fas and Bim synergistically control T-lymphocyte homeostatic proliferation

scientific article published on 27 October 2010

Cellular FLIP long form augments caspase activity and death of T cells through heterodimerization with and activation of caspase-8.

scientific article published in July 2005

Cellular FLIP long form-transgenic mice manifest a Th2 cytokine bias and enhanced allergic airway inflammation

scientific article published in April 2004

Conference highlight: do T cells care about the mitogen-activated protein kinase signalling pathways?

scientific article

Down-modulation of CD2 delays deletion of superantigen-responsive T cells ⬇️

scientific article published on 01 January 1998

Fas (CD95/APO-1) limits the expansion of T lymphocytes in an environment of limited T-cell antigen receptor/MHC contacts ⬇️

scientific article published on January 25, 2011

Fas ligand deficiency impairs host inflammatory response against infection with the spirochete Borrelia burgdorferi

scientific article

Fine-Tuning of CD8(+) T Cell Mitochondrial Metabolism by the Respiratory Chain Repressor MCJ Dictates Protection to Influenza Virus

scientific article published on 23 May 2016

Glycolysis Induces MCJ Expression That Links T Cell Proliferation With Caspase-3 Activity and Death

Glycolysis promotes caspase-3 activation in lipid rafts in T cells

scientific article published on 19 January 2018

IL-15 maintains T-cell survival via S-nitrosylation-mediated inhibition of caspase-3

scientific article

IL-6 promotes the differentiation of a subset of naive CD8+ T cells into IL-21-producing B helper CD8+ T cells.

scientific article published on 26 September 2016

Increased caspase activity primes human Lyme arthritis synovial γδ T cells for proliferation and death ⬇️

scientific article published on September 22, 2011

JNK, but not MAPK, activation is associated with Fas-mediated apoptosis in human T cells

scientific article published on May 1996

MCJ/DnaJC15, an endogenous mitochondrial repressor of the respiratory chain that controls metabolic alterations

scientific journal article

Mitochondrial ATP fuels ABC transporter-mediated drug efflux in cancer chemoresistance

scientific article

Necroptosis of Dendritic Cells Promotes Activation of γδ T Cells.

scientific article published on 19 July 2016

Proliferating γδ T cells manifest high and spatially confined caspase‐3 activity ⬇️

scientific article published on 01 April 2012

Protein disulfide isomerase-endoplasmic reticulum resident protein 57 regulates allergen-induced airways inflammation, fibrosis, and hyperresponsiveness

scientific article

Reduced immune response to Borrelia burgdorferi in the absence of γδ T cells.

scientific article

Selective DNA Demethylation Accompanies T Cell Homeostatic Proliferation and Gene Regulation in Lupus-Prone lpr Mice

scientific article published on 23 October 2020

Serum amyloid A inhibits dendritic cell apoptosis to induce glucocorticoid resistance in CD4(+) T cells

scientific article published on 05 September 2013

Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation

scientific article published on 03 July 2020

Sonoporation as an Approach for siRNA delivery into T cells

scientific article published on 17 September 2019

Targeting mitochondrial oxidative stress with MitoQ reduces NET formation and kidney disease in lupus-prone MRL-lpr mice

scientific article published on 16 April 2020

The c-FLIPL cleavage product p43FLIP promotes activation of extracellular signal-regulated kinase (ERK), nuclear factor κB (NF-κB), and caspase-8 and T cell survival

scientific article

The caspase 8 inhibitor c-FLIP(L) modulates T-cell receptor-induced proliferation but not activation-induced cell death of lymphocytes

scientific article

The death receptor Fas (CD95/APO-1) mediates the deletion of T lymphocytes undergoing homeostatic proliferation

scientific article published in October 2005

The molecular signature of murine T cell homeostatic proliferation reveals both inflammatory and immune inhibition patterns

scientific article

c-FLIP(S) reduces activation of caspase and NF-kappaB pathways and decreases T cell survival

scientific article published on January 2008

List of works by Karen A Fortner

Activation of gamma delta T cells by Borrelia burgdorferi is indirect via a TLR- and caspase-dependent pathway

Activation of the p38 mitogen-activated protein kinase pathway arrests cell cycle progression and differentiation of immature thymocytes in vivo

Apoptosis regulators Fas and Bim cooperate in shutdown of chronic immune responses and prevention of autoimmunity

Apoptosis regulators Fas and Bim synergistically control T-lymphocyte homeostatic proliferation

Cellular FLIP long form augments caspase activity and death of T cells through heterodimerization with and activation of caspase-8.

Cellular FLIP long form-transgenic mice manifest a Th2 cytokine bias and enhanced allergic airway inflammation

Conference highlight: do T cells care about the mitogen-activated protein kinase signalling pathways?

Down-modulation of CD2 delays deletion of superantigen-responsive T cells ⬇️

Fas (CD95/APO-1) limits the expansion of T lymphocytes in an environment of limited T-cell antigen receptor/MHC contacts ⬇️

Fas ligand deficiency impairs host inflammatory response against infection with the spirochete Borrelia burgdorferi

Fine-Tuning of CD8(+) T Cell Mitochondrial Metabolism by the Respiratory Chain Repressor MCJ Dictates Protection to Influenza Virus

Glycolysis Induces MCJ Expression That Links T Cell Proliferation With Caspase-3 Activity and Death

Glycolysis promotes caspase-3 activation in lipid rafts in T cells

IL-15 maintains T-cell survival via S-nitrosylation-mediated inhibition of caspase-3

IL-6 promotes the differentiation of a subset of naive CD8+ T cells into IL-21-producing B helper CD8+ T cells.

Increased caspase activity primes human Lyme arthritis synovial γδ T cells for proliferation and death ⬇️

JNK, but not MAPK, activation is associated with Fas-mediated apoptosis in human T cells

MCJ/DnaJC15, an endogenous mitochondrial repressor of the respiratory chain that controls metabolic alterations

Mitochondrial ATP fuels ABC transporter-mediated drug efflux in cancer chemoresistance

Necroptosis of Dendritic Cells Promotes Activation of γδ T Cells.

Proliferating γδ T cells manifest high and spatially confined caspase‐3 activity ⬇️

Protein disulfide isomerase-endoplasmic reticulum resident protein 57 regulates allergen-induced airways inflammation, fibrosis, and hyperresponsiveness

Reduced immune response to Borrelia burgdorferi in the absence of γδ T cells.

Selective DNA Demethylation Accompanies T Cell Homeostatic Proliferation and Gene Regulation in Lupus-Prone lpr Mice

Serum amyloid A inhibits dendritic cell apoptosis to induce glucocorticoid resistance in CD4(+) T cells

Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation

Sonoporation as an Approach for siRNA delivery into T cells

Targeting mitochondrial oxidative stress with MitoQ reduces NET formation and kidney disease in lupus-prone MRL-lpr mice

The c-FLIPL cleavage product p43FLIP promotes activation of extracellular signal-regulated kinase (ERK), nuclear factor κB (NF-κB), and caspase-8 and T cell survival

The caspase 8 inhibitor c-FLIP(L) modulates T-cell receptor-induced proliferation but not activation-induced cell death of lymphocytes

The death receptor Fas (CD95/APO-1) mediates the deletion of T lymphocytes undergoing homeostatic proliferation

The molecular signature of murine T cell homeostatic proliferation reveals both inflammatory and immune inhibition patterns

c-FLIP(S) reduces activation of caspase and NF-kappaB pathways and decreases T cell survival