List of works - Daniela Salvemini

A3 adenosine receptor agonist prevents the development of paclitaxel-induced neuropathic pain by modulating spinal glial-restricted redox-dependent signaling pathways.

scientific article published on 19 September 2014

Activation of Sphingosine-1-Phosphate Receptor 1 in the Spinal Cord Produces Mechanohypersensitivity Through the Activation of Inflammasome and IL-1β Pathway

scientific article published on 23 February 2019

Activation of sphingosine-1-phosphate receptor subtype 1 in the central nervous system contributes to morphine-induced hyperalgesia and antinociceptive tolerance in rodents

scientific article published on 13 April 2020

Adenosine A3 receptor as a novel therapeutic target to reduce secondary events and improve neurocognitive functions following traumatic brain injury

scientific article published on 12 November 2020

Anti-superoxide and anti-peroxynitrite strategies in pain suppression ⬇️

scientific article published on December 19, 2011

Bioenergetic deficits in peripheral nerve sensory axons during chemotherapy-induced neuropathic pain resulting from peroxynitrite-mediated post-translational nitration of mitochondrial superoxide dismutase

scientific article published on 25 July 2013

Chemotherapy-induced pain is promoted by enhanced spinal adenosine kinase levels via astrocyte-dependent mechanisms

scientific article

Controlling murine and rat chronic pain through A3 adenosine receptor activation

scientific article published on 17 February 2012

Counter-regulation of opioid analgesia by glial-derived bioactive sphingolipids

scientific article

DDD-028: a potent potential non-opioid, non-cannabinoid analgesic for neuropathic and inflammatory pain

scientific article

Design and in vivo activity of A3 adenosine receptor agonist prodrugs

scientific article published on 27 July 2020

Dysregulation of sphingolipid metabolism contributes to bortezomib-induced neuropathic pain.

scientific article published on 27 April 2018

Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states

scientific article

Engagement of the GABA to KCC2 signaling pathway contributes to the analgesic effects of A3AR agonists in neuropathic pain

scientific article

Exploration of Alternative Scaffolds for P2Y14 Receptor Antagonists Containing a Biaryl Core

scientific article published on 06 August 2020

Extended N(6) substitution of rigid C2-arylethynyl nucleosides for exploring the role of extracellular loops in ligand recognition at the A3 adenosine receptor.

scientific article

GPR160 de-orphanization reveals critical roles in neuropathic pain in rodents

scientific article published on 13 April 2020

GPR183-oxysterol axis in spinal cord contributes to neuropathic pain

scientific article published on 10 September 2020

Intraplantar-injected ceramide in rats induces hyperalgesia through an NF-κB- and p38 kinase-dependent cyclooxygenase 2/prostaglandin E2 pathway

scientific article

Manganese(III) Complexes of Bis(hydroxyphenyl)dipyrromethenes Are Potent Orally Active Peroxynitrite Scavengers ⬇️

scientific article published on March 3, 2011

Modulation of serum cytokine levels by a novel superoxide dismutase mimetic, M40401, in an Escherichia coli model of septic shock: correlation with preserved circulating catecholamines

scientific article published in January 2003

NMDA-receptor activation and nitroxidative regulation of the glutamatergic pathway during nociceptive processing

scientific article published on 18 February 2010

P2Y14 Receptor Antagonists Reverse Chronic Neuropathic Pain in a Mouse Model

scientific article published on 30 April 2020

Peripheral Adenosine A3 Receptor Activation Causes Regulated Hypothermia in Mice That Is Dependent on Central Histamine H1 Receptors.

scientific article

Peroxynitrite: a strategic linchpin of opioid analgesic tolerance

scientific article published on 02 March 2009

Purine (N)-Methanocarba Nucleoside Derivatives Lacking an Exocyclic Amine as Selective A3 Adenosine Receptor Agonists.

scientific article

Retooling manganese(III) porphyrin-based peroxynitrite decomposition catalysts for selectivity and oral activity: a potential new strategy for treating chronic pain

scientific article published on 22 November 2011

Rigidified A3 Adenosine Receptor Agonists: 1-Deazaadenine Modification Maintains High in Vivo Efficacy

scientific article published on 20 May 2015

Role for peroxynitrite in sphingosine-1-phosphate-induced hyperalgesia in rats ⬇️

scientific article published on January 15, 2011

Scaffold Repurposing of Nucleosides (Adenosine Receptor Agonists): Enhanced Activity at the Human Dopamine and Norepinephrine Sodium Symporters

scientific article

Sexually dimorphic therapeutic response in bortezomib-induced neuropathic pain reveals altered pain physiology in female rodents

scientific article published on 01 January 2020

Sphingosine 1-phosphate mediates hyperalgesia via a neutrophil-dependent mechanism

scientific article

Sphingosine-1-phosphate acting via the S1P₁ receptor is a downstream signaling pathway in ceramide-induced hyperalgesia

scientific article

Sphingosine-1-phosphate receptor 1 activation in astrocytes contributes to neuropathic pain

scientific article published on 08 May 2019

Sphingosine-1-phosphate receptor subtype 1 activation in the central nervous system contributes to morphine withdrawal in rodents

scientific article published on 22 October 2020

Spinal NADPH oxidase is a source of superoxide in the development of morphine-induced hyperalgesia and antinociceptive tolerance

scientific article

Spinal ceramide and neuronal apoptosis in morphine antinociceptive tolerance

scientific article published on 23 July 2009

Spinal mitochondrial-derived peroxynitrite enhances neuroimmune activation during morphine hyperalgesia and antinociceptive tolerance

scientific article published on 27 February 2013

Spinal neuroimmune activation is independent of T-cell infiltration and attenuated by A3 adenosine receptor agonists in a model of oxaliplatin-induced peripheral neuropathy

scientific article

Structure-Based Design, Synthesis by Click Chemistry and in Vivo Activity of Highly Selective A3 Adenosine Receptor Agonists

scientific article published in January 2015

Supraspinal Peroxynitrite Modulates Pain Signaling by Suppressing the Endogenous Opioid Pathway ⬇️

scientific article published on August 8, 2012

Targeting the S1P/S1PR1 axis mitigates cancer-induced bone pain and neuroinflammation

scientific article published on 31 May 2017

Targeting the overproduction of peroxynitrite for the prevention and reversal of paclitaxel-induced neuropathic pain

scientific article published on May 2012

The cystine/glutamate antiporter system xc- drives breast tumor cell glutamate release and cancer-induced bone pain

scientific article published on 02 August 2016

The development and maintenance of paclitaxel-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1.

scientific article

List of works by Daniela Salvemini

A3 adenosine receptor agonist prevents the development of paclitaxel-induced neuropathic pain by modulating spinal glial-restricted redox-dependent signaling pathways.

Activation of Sphingosine-1-Phosphate Receptor 1 in the Spinal Cord Produces Mechanohypersensitivity Through the Activation of Inflammasome and IL-1β Pathway

Activation of sphingosine-1-phosphate receptor subtype 1 in the central nervous system contributes to morphine-induced hyperalgesia and antinociceptive tolerance in rodents

Adenosine A3 receptor as a novel therapeutic target to reduce secondary events and improve neurocognitive functions following traumatic brain injury

Anti-superoxide and anti-peroxynitrite strategies in pain suppression ⬇️

Bioenergetic deficits in peripheral nerve sensory axons during chemotherapy-induced neuropathic pain resulting from peroxynitrite-mediated post-translational nitration of mitochondrial superoxide dismutase

Chemotherapy-induced pain is promoted by enhanced spinal adenosine kinase levels via astrocyte-dependent mechanisms

Controlling murine and rat chronic pain through A3 adenosine receptor activation

Counter-regulation of opioid analgesia by glial-derived bioactive sphingolipids

DDD-028: a potent potential non-opioid, non-cannabinoid analgesic for neuropathic and inflammatory pain

Design and in vivo activity of A3 adenosine receptor agonist prodrugs

Dysregulation of sphingolipid metabolism contributes to bortezomib-induced neuropathic pain.

Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states

Engagement of the GABA to KCC2 signaling pathway contributes to the analgesic effects of A3AR agonists in neuropathic pain

Exploration of Alternative Scaffolds for P2Y14 Receptor Antagonists Containing a Biaryl Core

Extended N(6) substitution of rigid C2-arylethynyl nucleosides for exploring the role of extracellular loops in ligand recognition at the A3 adenosine receptor.

GPR160 de-orphanization reveals critical roles in neuropathic pain in rodents

GPR183-oxysterol axis in spinal cord contributes to neuropathic pain

Intraplantar-injected ceramide in rats induces hyperalgesia through an NF-κB- and p38 kinase-dependent cyclooxygenase 2/prostaglandin E2 pathway

Manganese(III) Complexes of Bis(hydroxyphenyl)dipyrromethenes Are Potent Orally Active Peroxynitrite Scavengers ⬇️

Modulation of serum cytokine levels by a novel superoxide dismutase mimetic, M40401, in an Escherichia coli model of septic shock: correlation with preserved circulating catecholamines

NMDA-receptor activation and nitroxidative regulation of the glutamatergic pathway during nociceptive processing

P2Y14 Receptor Antagonists Reverse Chronic Neuropathic Pain in a Mouse Model

Peripheral Adenosine A3 Receptor Activation Causes Regulated Hypothermia in Mice That Is Dependent on Central Histamine H1 Receptors.

Peroxynitrite: a strategic linchpin of opioid analgesic tolerance

Purine (N)-Methanocarba Nucleoside Derivatives Lacking an Exocyclic Amine as Selective A3 Adenosine Receptor Agonists.

Retooling manganese(III) porphyrin-based peroxynitrite decomposition catalysts for selectivity and oral activity: a potential new strategy for treating chronic pain

Rigidified A3 Adenosine Receptor Agonists: 1-Deazaadenine Modification Maintains High in Vivo Efficacy

Role for peroxynitrite in sphingosine-1-phosphate-induced hyperalgesia in rats ⬇️

Scaffold Repurposing of Nucleosides (Adenosine Receptor Agonists): Enhanced Activity at the Human Dopamine and Norepinephrine Sodium Symporters

Sexually dimorphic therapeutic response in bortezomib-induced neuropathic pain reveals altered pain physiology in female rodents

Sphingosine 1-phosphate mediates hyperalgesia via a neutrophil-dependent mechanism

Sphingosine-1-phosphate acting via the S1P₁ receptor is a downstream signaling pathway in ceramide-induced hyperalgesia

Sphingosine-1-phosphate receptor 1 activation in astrocytes contributes to neuropathic pain

Sphingosine-1-phosphate receptor subtype 1 activation in the central nervous system contributes to morphine withdrawal in rodents

Spinal NADPH oxidase is a source of superoxide in the development of morphine-induced hyperalgesia and antinociceptive tolerance

Spinal ceramide and neuronal apoptosis in morphine antinociceptive tolerance

Spinal mitochondrial-derived peroxynitrite enhances neuroimmune activation during morphine hyperalgesia and antinociceptive tolerance

Spinal neuroimmune activation is independent of T-cell infiltration and attenuated by A3 adenosine receptor agonists in a model of oxaliplatin-induced peripheral neuropathy

Structure-Based Design, Synthesis by Click Chemistry and in Vivo Activity of Highly Selective A3 Adenosine Receptor Agonists

Supraspinal Peroxynitrite Modulates Pain Signaling by Suppressing the Endogenous Opioid Pathway ⬇️

Targeting the S1P/S1PR1 axis mitigates cancer-induced bone pain and neuroinflammation

Targeting the overproduction of peroxynitrite for the prevention and reversal of paclitaxel-induced neuropathic pain

The cystine/glutamate antiporter system xc- drives breast tumor cell glutamate release and cancer-induced bone pain

The development and maintenance of paclitaxel-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1.