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List of works by Iqbal S Grewal

5-azacytidine enhances the anti-leukemic activity of lintuzumab (SGN-33) in preclinical models of acute myeloid leukemia

scientific article

A central role of CD40 ligand in the regulation of CD4+ T-cell responses

scientific article published on September 1996

A crucial role of CD4 T cells as a functional source of CD154 in the initiation of insulin-dependent diabetes mellitus in the non-obese diabetic mouse

scientific article published on 01 March 2003

A novel in vivo role for osteoprotegerin ligand in activation of monocyte effector function and inflammatory response

scientific article

A soluble BAFF antagonist, BR3-Fc, decreases peripheral blood B cells and lymphoid tissue marginal zone and follicular B cells in cynomolgus monkeys

scientific article

APRIL-deficient mice have normal immune system development

scientific journal article

Activation and accumulation of B cells in TACI-deficient mice

scientific article published on 01 July 2001

Anti-leukemic activity of lintuzumab (SGN-33) in preclinical models of acute myeloid leukemia

scientific article published on 15 September 2009

Antibody drug-conjugates targeting the tumor vasculature: Current and future developments

scientific article

Antibody targeting of B-cell maturation antigen on malignant plasma cells

scientific article published on November 2007

Autoimmune lpr/lpr mice deficient in CD40 ligand: spontaneous Ig class switching with dichotomy of autoantibody responses

scientific article published on 01 July 1996

BAFF/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-kappaB2

scientific article

Bispecific Antibodies for Triple Negative Breast Cancer

scientific article published on 08 October 2020

Blocking of CD27-CD70 pathway by anti-CD70 antibody ameliorates joint disease in murine collagen-induced arthritis

scientific article published on 26 August 2009

CD27-CD70 interactions in the pathogenesis of Waldenstrom macroglobulinemia.

scientific article published on 23 January 2008

CD30 expression on CD1a+ and CD8+ cells in atopic dermatitis and correlation with disease severity

scientific article published on 18 December 2007

CD40 AND CD154 IN CELL-MEDIATED IMMUNITY

scientific article

CD40 expression on antigen presenting cells and correlation with disease severity in atopic dermatitis

scientific article published on 08 August 2008

CD40 ligand-deficient mice generate a normal primary cytotoxic T-lymphocyte response but a defective humoral response to a viral infection

scientific article published in December 1996

CD40 ligand-mediated interactions are involved in the generation of memory CD8(+) cytotoxic T lymphocytes (CTL) but are not required for the maintenance of CTL memory following virus infection

scientific article

CD40-CD40 ligand costimulation is required for generating antiviral CD4 T cell responses but is dispensable for CD8 T cell responses

scientific article published on 01 September 1999

CD40L is important for induction of, but not response to, costimulatory activity. ICAM-1 as the second costimulatory molecule rapidly up-regulated by CD40L.

scientific article published on October 1996

CD40L-deficient mice show deficits in antiviral immunity and have an impaired memory CD8+ CTL response.

scientific article published on May 1996

CD62L is required on effector cells for local interactions in the CNS to cause myelin damage in experimental allergic encephalomyelitis

scientific article published on 01 March 2001

Combination of the anti-CD30-auristatin-E antibody-drug conjugate (SGN-35) with chemotherapy improves antitumour activity in Hodgkin lymphoma

scientific article

Disruption of CD40-CD40 ligand interactions results in an enhanced susceptibility to Leishmania amazonensis infection

scientific article published in March 1996

Distinct apoptotic signaling characteristics of the anti-CD40 monoclonal antibody dacetuzumab and rituximab produce enhanced antitumor activity in non-Hodgkin lymphoma

scientific article published on 24 May 2011

Emerging CAR-T Cell Therapy for the Treatment of Triple Negative Breast Cancer

scientific article published on 21 October 2020

Engineered anti-CD70 antibody with multiple effector functions exhibits in vitro and in vivo antitumor activities

scientific article published on 12 October 2006

Expression of activated CDC42 induces T cell apoptosis in thymus and peripheral lymph organs via different pathways

scientific article published on 01 December 1999

Expression of transgene encoded TGF-beta in islets prevents autoimmune diabetes in NOD mice by a local mechanism.

scientific article published in August 2002

Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency

scientific article (publication date: 2 October 2001)

Identification of a receptor for BLyS demonstrates a crucial role in humoral immunity

scientific article (publication date: July 2000)

Immunomodulatory drug lenalidomide (CC-5013, IMiD3) augments anti-CD40 SGN-40-induced cytotoxicity in human multiple myeloma: clinical implications

scientific article published on December 2005

Impaired T cell-mediated macrophage activation in CD40 ligand-deficient mice

scientific article published on 01 January 1996

Impaired c-Jun amino terminal kinase activity and T cell differentiation in death receptor 6-deficient mice

scientific article

Impaired primary T cell responses in L-selectin-deficient mice

scientific article

Impairment of antigen-specific T-cell priming in mice lacking CD40 ligand

scientific article

In vivo properties of monocyte chemoattractant protein-1.

scientific article published on November 1997

Local expression of transgene encoded TNF alpha in islets prevents autoimmune diabetes in nonobese diabetic (NOD) mice by preventing the development of auto-reactive islet-specific T cells

scientific article

Loss of TACI causes fatal lymphoproliferation and autoimmunity, establishing TACI as an inhibitory BLyS receptor

scientific article

Macrophages and Fc-receptor interactions contribute to the antitumour activities of the anti-CD40 antibody SGN-40.

scientific article

Macrophages contribute to the antitumor activity of the anti-CD30 antibody SGN-30.

scientific article

Modulation of the immunogenicity of antigenic determinants by their flanking residues ⬇️

scientific article published on May 1, 1998

NTB-A, a new activating receptor in T cells that regulates autoimmune disease

scientific article

New insights into insulin dependent diabetes mellitus from studies with transgenic mouse models

scientific article

Novel antibody-based therapeutic agents targeting CD70: a potential approach for treating Waldenström's macroglobulinemia

scientific article published on March 2009

Potent anticarcinoma activity of the humanized anti-CD70 antibody h1F6 conjugated to the tubulin inhibitor auristatin via an uncleavable linker

scientific article published on 22 September 2008

Potent antitumor activity of the anti-CD19 auristatin antibody drug conjugate hBU12-vcMMAE against rituximab-sensitive and -resistant lymphomas

scientific article

Preclinical antilymphoma activity of a humanized anti-CD40 monoclonal antibody, SGN-40.

scientific article published on September 2005

Preclinical characterization of SGN-70, a humanized antibody directed against CD70

scientific article published on 01 December 2008

Preclinical pharmacokinetics, pharmacodynamics and activity of a humanized anti-CD40 antibody (SGN-40) in rodents and non-human primates.

scientific article published on 22 January 2007

Preclinical pharmacokinetics, pharmacodynamics, and activity of a humanized anti-CD40 antibody (SGN-40) in rodents and non-human primates

scientific article published on 10 July 2006

Proapoptotic signaling activity of the anti-CD40 monoclonal antibody dacetuzumab circumvents multiple oncogenic transformation events and chemosensitizes NHL cells

scientific article published on 11 March 2011

Protective antibodies in murine Lyme disease arise independently of CD40 ligand

scientific article published on 01 July 1996

Rapid induction of a novel costimulatory activity on B cells by CD40 ligand.

scientific article published on November 1995

Recombinant humanized anti-CD40 monoclonal antibody triggers autologous antibody-dependent cell-mediated cytotoxicity against multiple myeloma cells

scientific article published on 01 May 2003

Reconstitution of invariant chain function in transgenic mice in vivo by individual p31 and p41 isoforms

scientific article published on 01 September 1995

Regulatory T Cell targeting in cancer: Emerging strategies in immunotherapy

scientific article published on 10 December 2020

Requirement for CD154 in the progression of atherosclerosis

scientific article published in November 1999

Requirement for CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitis

scientific article published in September 1996

Response to 'Secreted IgM versus BLyS in germinal center formation'

scientific article published on 01 September 2000

Role of L-selectin in the development of autoimmune diabetes in non-obese diabetic mice

scientific article published on 01 February 2004

TACI-ligand interactions are required for T cell activation and collagen-induced arthritis in mice

scientific article published on 01 July 2001

TNF-related apoptosis-inducing ligand (TRAIL)/Apo2L suppresses experimental autoimmune encephalomyelitis in mice

scientific article published on 01 October 2005

Targeting CD30/CD30L in oncology and autoimmune and inflammatory diseases

scientific article published on January 2009

Targeting CD70 for human therapeutic use.

scientific article published on January 2009

Targeting inflammatory cells to improve anti-VEGF therapies in oncology

scientific article published on January 2010

Targeting of BAFF and APRIL for autoimmunity and oncology

scientific article published on January 2009

The CD40 ligand. At the center of the immune universe?

scientific article published on February 1997

The CD40-CD154 system in anti-infective host defense

scientific article published on August 1997

The Influence of Mouse Housing Density on Autoimmune Reactivity ⬇️

scientific article published on January 1, 1997

The role of CD40 ligand in costimulation and T-cell activation

scientific article

Therapeutic interventions targeting CD40L (CD154) and CD40: the opportunities and challenges

scientific article

Transgenic monocyte chemoattractant protein-1 (MCP-1) in pancreatic islets produces monocyte-rich insulitis without diabetes: abrogation by a second transgene expressing systemic MCP-1

scientific article published on 01 July 1997

Transient subversion of CD40 ligand function diminishes immune responses to adenovirus vectors in mouse liver and lung tissues

scientific article published in September 1996

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