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List of works by Jaime Guevara-Aguirre

A novel variant in CDKN1C is associated with intrauterine growth restriction, short stature, and early-adulthood-onset diabetes

scientific article

A randomized, double blind, placebo-controlled trial on safety and efficacy of recombinant human insulin-like growth factor-I in children with growth hormone receptor deficiency

scientific article published on 01 April 1995

Absence of hypoglycemia in response to varying doses of recombinant human insulin-like growth factor-I (rhIGF-I) in children and adolescents with low serum concentrations of IGF-I.

scientific article published in February 2006

Accurate determination of height using an inexpensive measuring device

scientific article published in March 1994

Assessing insulin sensitivity and resistance in syndromes of severe short stature

scientific article published on 28 July 2020

Beneficial effects of addition of oral spray insulin (Oralin) on insulin secretion and metabolic control in subjects with type 2 diabetes mellitus suboptimally controlled on oral hypoglycemic agents

scientific article published in February 2004

Body changes in adolescent patients with growth hormone receptor deficiency receiving recombinant human insulin-like growth factor I and luteinizing hormone-releasing hormone analogue: preliminary results

scientific article published on 01 April 1994

Bone Mineral, Histomorphometry, and Body Composition in Adults with Growth Hormone Receptor Deficiency ⬇️

scientific article published on March 1, 1998

Brain Structure and Function Associated with Younger Adults in Growth Hormone Receptor-Deficient Humans.

scientific article published on 10 January 2017

Branched Chain and Aromatic Amino Acids Are Associated With Insulin Resistance During Pubertal Development in Girls

scientific article published on 01 September 2019

Branding of subjects affected with genetic syndromes of severe short stature in developing countries

scientific article published on 09 February 2020

Clinical and biochemical characteristics of growth hormone receptor deficiency (Laron syndrome).

scientific article published on September 1992

Comparison of oral insulin spray and subcutaneous regular insulin at mealtime in type 1 diabetes

scientific article published on 01 August 2007

Controversy in clinical endocrinology: reclassification of insulin-like growth factor I production and action disorders

scientific article published on 05 September 2006

Despite higher body fat content, Ecuadorian subjects with Laron syndrome have less insulin resistance and lower incidence of diabetes than their relatives

scientific article published on 5 August 2015

Diverse growth hormone receptor gene mutations in Laron syndrome.

scientific article

Effects of heterozygosity for the E180 splice mutation causing growth hormone receptor deficiency in Ecuador on IGF-I, IGFBP-3, and stature

scientific article published on 09 March 2007

Effects of insulin‐like growth factor I treatment on the molecular distribution of insulin‐like growth factors among different binding proteins ⬇️

scientific article published on April 1, 1994

Expression of serum insulin-like growth factors, insulin-like growth factor-binding proteins, and the growth hormone-binding protein in heterozygote relatives of Ecuadorian growth hormone receptor deficient patients

scientific article published on April 1, 1992

Facial morphometry of Ecuadorian patients with growth hormone receptor deficiency/Laron syndrome

scientific article

Filter Paper Blood Spot Assay of Human Insulin-Like Growth Factor I (IGF-I) and IGF-Binding Protein-3 and Preliminary Application in the Evaluation of Growth Hormone Status ⬇️

scientific article published on July 1, 1998

Foreword from the editors.

scientific article

Foreword from the guest editors

scientific article published on 01 August 2020

Foreword from the guest editors.

scientific article published on 28 December 2017

GH Receptor Deficiency in Ecuadorian Adults Is Associated With Obesity and Enhanced Insulin Sensitivity

scientific article published on 18 May 2015

GH and GHR signaling in human disease

scientific article published on 12 December 2017

Growth hormone (GH) insensitivity and insulin-like growth factor-I deficiency in Inuit subjects and an Ecuadorian cohort: functional studies of two codon 180 GH receptor gene mutations

scientific article

Growth hormone (GH) insensitivity due to primary GH receptor deficiency

scientific article published on June 1994

Growth hormone insensitivity

scientific article published on April 1997

Growth hormone insensitivity.

scientific article published on January 1997

Growth hormone receptor deficiency (Laron syndrome): clinical and genetic characteristics

scientific article published on January 1991

Growth hormone receptor deficiency in Ecuador

scientific article

Growth hormone receptor deficiency in Ecuador: clinical and biochemical phenotype in two populations ⬇️

scientific article published on 01 February 1993

Growth hormone receptor deficiency in South America: colonial history, molecular biology, and growth and metabolic insights.

scientific article published in December 2008

Growth hormone receptor deficiency in humans associates to obesity, increased body fat percentage, a healthy brain and a coordinated insulin sensitivity

scientific article published on 19 February 2020

Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans

scientific article

Growth in growth hormone insensitivity

scientific article published on 01 September 1994

Heart rate increases in patients with growth hormone receptor deficiency treated with insulin-like growth factor I

scientific article published on 01 April 1994

Hormonal and metabolic effects and pharmacokinetics of recombinant insulin-like growth factor-I in growth hormone receptor deficiency/Laron syndrome ⬇️

scientific article published on 01 July 1993

IGF generation in short stature

scientific article published on 01 December 2002

IGF-I deficiency and enhanced insulin sensitivity due to a mutated growth hormone receptor gene in humans

scientific article published on 11 October 2020

IGF-I regulates the age-dependent signaling peptide humanin.

scientific article

Immunoblot studies of the acid‐labile subunit (ALS) in biological fluids, normal human serum and in children with GH deficiency and GH receptor deficiency before and after long‐term therapy with GH or IGF‐I respectively ⬇️

scientific article published on December 1, 1997

Insights from the clinical phenotype of subjects with Laron syndrome in Ecuador

scientific article published on 12 October 2020

Insulin resistance depends on GH counter-regulation in two syndromes of short stature

scientific article published on 20 December 2017

Insulin-like growth factor (IGF) parameters and tools for efficacy: the IGF-I generation test in children

scientific article

Insulin-like growth factor I--an important intrauterine growth factor

scientific article published on 01 October 1996

Insulin-like growth factor binding protein-3 generation as a measure of GH sensitivity

scientific article published in October 2002

Intrauterine and postnatal growth failure with normal GH/IGF1 axis and insulin-resistant diabetes in a consanguineous kinship ⬇️

scientific article published on December 14, 2011

Is there heterozygote expression of growth hormone receptor deficiency?

scientific article published on 01 April 1994

Kinetics of Insulin-Like Growth Factor (IGF) and IGF-Binding Protein Responses to a Single Dose of Growth Hormone1 ⬇️

scientific article published on July 1, 1997

Leptin concentrations in GH deficiency: the effect of GH insensitivity

scientific article published on February 2002

Lessons from the genetics of laron syndrome

scientific article published on 01 September 1998

Long-term effects of insulin-like growth factor (IGF)-I treatment on serum IGFs and IGF binding proteins in adolescent patients with growth hormone receptor deficiency

scientific article published on 01 April 1995

Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population.

scientific article

Meeting Report: The 2015-USFQ Biennial Meeting on Growth Hormone Research

Meeting Reports: The 2017-USFQ Biennial Meeting on Growth Hormone and IGF1 Research

scientific article published on 01 December 2017

Mutation creating a new splice site in the growth hormone receptor genes of 37 Ecuadorean patients with Laron syndrome ⬇️

scientific article published on January 1, 1992

Natural history of growth hormone receptor deficiency.

scientific article

Normal Intelligence with Severe Insulin-Like Growth Factor I Deficiency due to Growth Hormone Receptor Deficiency: A Controlled Study in a Genetically Homogeneous Population1 ⬇️

scientific article published on June 1, 1998

Obesity, diabetes and cancer: insight into the relationship from a cohort with growth hormone receptor deficiency

scientific article

Obesity, the Cinderella of Clinical Medicine

scientific article published on 14 August 2020

Oral spray insulin in treatment of type 2 diabetes: a comparison of efficacy of the oral spray insulin (Oralin) with subcutaneous (SC) insulin injection, a proof of concept study

scientific article published in November 2004

PRISMATIC case: bienvenidos a mi tierra de soledad: from poetry to molecular biology in southern Ecuador

scientific article

Pharmacokinetics of recombinant human insulin-like growth factor I given subcutaneously to healthy volunteers and to patients with growth hormone receptor deficiency

scientific article published on 01 September 1993

Physician's role in prescribing opioids in developing countries

scientific article published on 02 June 2019

Receptor mutations and haplotypes in growth hormone receptor deficiency: a global survey and identification of the Ecuadorean E180splice mutation in an oriental Jewish patient

scientific article published in April 1994

Recombinant human insulin-like growth factor I has significant anabolic effects in adults with growth hormone receptor deficiency: studies on protein, glucose, and lipid metabolism

scientific article published on 01 September 2000

Recommended IGF-I Dosage Causes Greater Fat Accumulation and Osseous Maturation Than Lower Dosage and May Compromise Long-term Growth Effects ⬇️

scientific article published on January 22, 2013

Regulation of Serum Insulin-Like Growth Factors and Their Binding Proteins in Ecuadorean Patients with Growth Hormone Receptor Dysfunction (Growth Hormone Insensitivity) ⬇️

scientific article published on January 1, 1991

Reproducibility in Patterns of IGF Generation with Special Reference to Idiopathic Short Stature ⬇️

scientific article published on 01 January 2003

Ring chromosome 15 - cytogenetics and mapping arrays: a case report and review of the literature

scientific article published on 16 November 2018

Serum levels of insulin-like growth factor binding proteins in Ecuadorean children with growth hormone insensitivity

scientific article published on 01 February 1999

Serum profiles of insulin‐like growth factors and their binding proteins in adults with growth hormone receptor deficiency treated with insulin like growth factor I ⬇️

scientific article published on March 1, 1993

Stature in Ecuadorians Heterozygous for Growth Hormone Receptor Gene E180 Splice Mutation Does Not Differ From That of Homozygous Normal Relatives1 ⬇️

scientific article published on July 1, 1998

The E180splice mutation in theGHRgene causing Laron syndrome: Witness of a Sephardic Jewish exodus from the Iberian Peninsula to the New World?

scientific article published on 24 March 2014

The IGF-I Generation Test Revisited: A Marker of GH Sensitivity ⬇️

scientific article published on 01 November 2001

The composition and distribution of insulin-like growth factors (IGFs) and IGF-binding proteins (IGFBPs) in the serum of growth hormone receptor-deficient patients: effects of IGF-I therapy on IGFBP-3.

scientific article published in December 1993

Treatment of growth failure in the absence of GH signaling: The Ecuadorian experience

scientific article published on 20 December 2017

Two-year treatment of growth hormone (GH) receptor deficiency with recombinant insulin-like growth factor I in 22 children: comparison of two dosage levels and to GH-treated GH deficiency

scientific article published on 01 February 1997

WHO and national lists of essential medicines in Mexico, Central and South America, and the Caribbean: are they adequate to promote paediatric endocrinology and diabetes care?

scientific article

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