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List of works by A John Iafrate

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Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer

scientific article
Detection of large-scale variation in the human genome

scientific article (publication date: September 2004)
Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors

scientific article
Preexistence and clonal selection of MET amplification in EGFR mutant NSCLC.

scientific article
Mechanisms of Acquired Crizotinib Resistance in ALK-Rearranged Lung Cancers

scientific article published on January 25, 2012
Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs

scientific article
ROS1 rearrangements define a unique molecular class of lung cancers

scientific article
Crizotinib in ROS1-rearranged non-small-cell lung cancer.

scientific article
Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: a retrospective analysis

scientific article
Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification

scientific article
Frequent Mutation of Isocitrate Dehydrogenase (IDH)1 and IDH2 in Cholangiocarcinoma Identified Through Broad-Based Tumor Genotyping

scientific article published on December 16, 2011
Unique clinicopathologic features characterize ALK-rearranged lung adenocarcinoma in the western population

scientific article
Patient-derived models of acquired resistance can identify effective drug combinations for cancer.

scientific article
Aberrant overexpression of satellite repeats in pancreatic and other epithelial cancers

scientific article
Rapid targeted mutational analysis of human tumours: a clinical platform to guide personalized cancer medicine

scientific article published on May 2010
Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors

scientific article
MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib

scientific article published on 31 October 2011
A Novel, Highly Sensitive Antibody Allows for the Routine Detection ofALK-Rearranged Lung Adenocarcinomas by Standard Immunohistochemistry

scientific article published on February 23, 2010
ALK Rearrangements Are Mutually Exclusive with Mutations in EGFR or KRAS: An Analysis of 1,683 Patients with Non–Small Cell Lung Cancer

scientific article published on May 31, 2013
Activity of crizotinib (PF02341066), a dual mesenchymal-epithelial transition (MET) and anaplastic lymphoma kinase (ALK) inhibitor, in a non-small cell lung cancer patient with de novo MET amplification

scientific article
BRAF gene amplification can promote acquired resistance to MEK inhibitors in cancer cells harboring the BRAF V600E mutation

scientific article published on November 23, 2010
Heterogeneity Underlies the Emergence of EGFRT790 Wild-Type Clones Following Treatment of T790M-Positive Cancers with a Third-Generation EGFR Inhibitor

scientific article published on May 2015
Loss of the mismatch repair protein MSH6 in human glioblastomas is associated with tumor progression during temozolomide treatment

scientific article
Resensitization to Crizotinib by the Lorlatinib ALK Resistance Mutation L1198F.

scientific article
An X chromosome gene, WTX, is commonly inactivated in Wilms tumor

scientific article
Activity of IPI-504, a Novel Heat-Shock Protein 90 Inhibitor, in Patients With Molecularly Defined Non–Small-Cell Lung Cancer

scientific article published on October 12, 2010
Two novel ALK mutations mediate acquired resistance to the next-generation ALK inhibitor alectinib

scientific article
NCCN Task Force Report: Evaluating the Clinical Utility of Tumor Markers in Oncology

scientific article published on November 1, 2011
Acquired Resistance to Crizotinib from a Mutation in CD74 – ROS1

scientific article
BRAF V600E mutations are common in pleomorphic xanthoastrocytoma: diagnostic and therapeutic implications

scientific article
Clinical Acquired Resistance to RAF Inhibitor Combinations in BRAF-Mutant Colorectal Cancer through MAPK Pathway Alterations

scientific article
Multi-institutional Oncogenic Driver Mutation Analysis in Lung Adenocarcinoma: The Lung Cancer Mutation Consortium Experience

scientific article published on May 2015
A Platform for Rapid Detection of Multiple Oncogenic Mutations With Relevance to Targeted Therapy in Non–Small-Cell Lung Cancer

scientific article published on December 23, 2010
Spectrum of Oncogenic Driver Mutations in Lung Adenocarcinomas from East Asian Never Smokers

scientific article published on November 30, 2011
Phase 1/2 study of everolimus in advanced hepatocellular carcinoma

scientific article
Mucinous differentiation correlates with absence of EGFR mutation and presence of KRAS mutation in lung adenocarcinomas with bronchioloalveolar features

scientific article
Routine multiplex mutational profiling of melanomas enables enrollment in genotype-driven therapeutic trials

scientific article (publication date: 2012)
Clinical significance of TTF-1 protein expression and TTF-1 gene amplification in lung adenocarcinoma

scientific article
Epithelial to mesenchymal transition is impaired in colon cancer cells with microsatellite instability

scientific article
Molecular Heterogeneity and Receptor Coamplification Drive Resistance to Targeted Therapy in MET-Amplified Esophagogastric Cancer

scientific article published on 2 October 2015
EZH2 codon 641 mutations are common in BCL2-rearranged germinal center B cell lymphomas

scientific article (publication date: 2011)
Rapid Radiographic and Clinical Improvement After Treatment of a MET-Amplified Recurrent Glioblastoma With a Mesenchymal-Epithelial Transition Inhibitor

scientific article published on December 12, 2011
Prospective serial evaluation of 2-hydroxyglutarate, during treatment of newly diagnosed acute myeloid leukemia, to assess disease activity and therapeutic response

scientific article published on October 16, 2012
Targetable signaling pathway mutations are associated with malignant phenotype in IDH-mutant gliomas.

scientific article
Circulating Oncometabolite 2-Hydroxyglutarate Is a Potential Surrogate Biomarker in Patients with Isocitrate Dehydrogenase-Mutant Intrahepatic Cholangiocarcinoma

scientific article published on January 29, 2014
Recurrent Chromosomal Copy Number Alterations in Sporadic Chordomas

scientific article published on May 13, 2011
Differential expression of microRNA (miRNA) in chordoma reveals a role for miRNA-1 in Met expression

scientific article published in June 2010
Histologic and cytomorphologic features of ALK-rearranged lung adenocarcinomas

scientific article published on June 29, 2012
The challenges posed by cancer heterogeneity

scientific article (publication date: 10 July 2012)
Standardized decision support in next generation sequencing reports of somatic cancer variants

scientific article published on 04 April 2014

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