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List of works by A John Iafrate

A Platform for Rapid Detection of Multiple Oncogenic Mutations With Relevance to Targeted Therapy in Non–Small-Cell Lung Cancer ⬇️

scientific article published on December 23, 2010

A novel, highly sensitive antibody allows for the routine detection of ALK-rearranged lung adenocarcinomas by standard immunohistochemistry

scientific article

A potential role for targeted therapy in a subset of metastasizing adnexal carcinomas ⬇️

scientific article published on March 18, 2011

ALK Rearrangements Are Mutually Exclusive with Mutations in EGFR or KRAS: An Analysis of 1,683 Patients with Non–Small Cell Lung Cancer ⬇️

scientific article published on May 31, 2013

Aberrant overexpression of satellite repeats in pancreatic and other epithelial cancers

scientific article

Acquired Resistance to Crizotinib from a Mutation in CD74 – ROS1

scientific article

Acquired Resistance to Crizotinib in NSCLC with MET Exon 14 Skipping

scientific article published on 22 June 2016

Activity of IPI-504, a Novel Heat-Shock Protein 90 Inhibitor, in Patients With Molecularly Defined Non–Small-Cell Lung Cancer ⬇️

scientific article published on October 12, 2010

Activity of crizotinib (PF02341066), a dual mesenchymal-epithelial transition (MET) and anaplastic lymphoma kinase (ALK) inhibitor, in a non-small cell lung cancer patient with de novo MET amplification

scientific article

An X chromosome gene, WTX, is commonly inactivated in Wilms tumor

scientific article

Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer

scientific article

Apocrine-Eccrine Carcinomas: Molecular and Immunohistochemical Analyses ⬇️

scientific article published on October 9, 2012

BRAF V600E Mutation Identifies a Subset of Low-Grade Diffusely Infiltrating Gliomas in Adults ⬇️

scientific article published on May 10, 2013

BRAF V600E mutations are common in pleomorphic xanthoastrocytoma: diagnostic and therapeutic implications

scientific article

BRAF gene amplification can promote acquired resistance to MEK inhibitors in cancer cells harboring the BRAF V600E mutation ⬇️

scientific article published on November 23, 2010

Biliary Adenofibroma of Liver: Morphology, Tumor Genetics, and Outcomes in 6 Cases

scientific article published on 6 March 2017

Characterization and analysis of human chordoma cell lines

scientific article published in June 2010

Circulating oncometabolite 2-hydroxyglutarate is a potential surrogate biomarker in patients with isocitrate dehydrogenase-mutant intrahepatic cholangiocarcinoma

scientific article

Clinical Acquired Resistance to RAF Inhibitor Combinations in BRAF-Mutant Colorectal Cancer through MAPK Pathway Alterations

scientific article

Clinical Grade "SNaPshot" Genetic Mutation Profiling in Multiple Myeloma

scientific article

Clinical significance of TTF-1 protein expression and TTF-1 gene amplification in lung adenocarcinoma

scientific article

Colorectal cancer in Crohn's colitis is comparable to sporadic colorectal cancer.

scientific article published on 30 March 2016

Combination of PI3K/mTOR inhibition demonstrates efficacy in human chordoma.

scientific article published in June 2009

Crizotinib in ROS1-rearranged non-small-cell lung cancer.

scientific article

Decreased survival in EGFR gene amplified vulvar carcinoma

scientific article published on 3 September 2008

Dendritic Cells in Kidney Transplant Biopsy Samples Are Associated with T Cell Infiltration and Poor Allograft Survival

scientific article

Detection of Dual IDH1 and IDH2 Mutations by Targeted Next-Generation Sequencing in Acute Myeloid Leukemia and Myelodysplastic Syndromes.

scientific article

Detection of large-scale variation in the human genome

scientific article (publication date: September 2004)

Differential expression of microRNA (miRNA) in chordoma reveals a role for miRNA-1 in Met expression

scientific article published in June 2010

EZH2 codon 641 mutations are common in BCL2-rearranged germinal center B cell lymphomas

scientific article (publication date: 2011)

Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: a retrospective analysis

scientific article

Elevation of Urinary 2-Hydroxyglutarate in IDH-Mutant Glioma

scientific article published on February 2016

Epithelial to mesenchymal transition is impaired in colon cancer cells with microsatellite instability

scientific article

Frequent Mutation of Isocitrate Dehydrogenase (IDH)1 and IDH2 in Cholangiocarcinoma Identified Through Broad-Based Tumor Genotyping ⬇️

scientific article published on December 16, 2011

Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors

scientific article

Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors

scientific article

Heterogeneity Underlies the Emergence of EGFRT790 Wild-Type Clones Following Treatment of T790M-Positive Cancers with a Third-Generation EGFR Inhibitor

scientific article published on May 2015

High lung shunt fraction in colorectal liver tumors is associated with distant metastasis and decreased survival

scientific article

Histologic and cytomorphologic features of ALK-rearranged lung adenocarcinomas ⬇️

scientific article published on June 29, 2012

Inactivation of the tumor suppressor WTX in a subset of pediatric tumors

scientific article published on 05 November 2013

Inconsistency and features of single nucleotide variants detected in whole exome sequencing versus transcriptome sequencing: A case study in lung cancer

scientific article published on 23 April 2015

Loss of the mismatch repair protein MSH6 in human glioblastomas is associated with tumor progression during temozolomide treatment

scientific article

MET Exon 14 Skipping in Non-Small Cell Lung Cancer.

scientific article published on 28 March 2016

MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib

scientific article published on 31 October 2011

Mechanisms of Acquired Crizotinib Resistance in ALK-Rearranged Lung Cancers ⬇️

scientific article published on January 25, 2012

Molecular Heterogeneity and Receptor Coamplification Drive Resistance to Targeted Therapy in MET-Amplified Esophagogastric Cancer

scientific article published on 2 October 2015

Mucinous differentiation correlates with absence of EGFR mutation and presence of KRAS mutation in lung adenocarcinomas with bronchioloalveolar features

scientific article

Multi-institutional Oncogenic Driver Mutation Analysis in Lung Adenocarcinoma: The Lung Cancer Mutation Consortium Experience

scientific article published on May 2015

NCCN Task Force Report: Evaluating the Clinical Utility of Tumor Markers in Oncology ⬇️

scientific article published on November 1, 2011

Patient-derived models of acquired resistance can identify effective drug combinations for cancer.

scientific article

Persistence and decay of human antibody responses to the receptor binding domain of SARS-CoV-2 spike protein in COVID-19 patients

scientific article published on 01 October 2020

Phase 1/2 study of everolimus in advanced hepatocellular carcinoma

scientific article

Polysomy for chromosomes 1 and 19 predicts earlier recurrence in anaplastic oligodendrogliomas with concurrent 1p/19q loss.

scientific article

Preexistence and clonal selection of MET amplification in EGFR mutant NSCLC.

scientific article

Prognosis and Clinicopathologic Features of Patients With Advanced Stage Isocitrate Dehydrogenase (IDH) Mutant and IDH Wild-Type Intrahepatic Cholangiocarcinoma

scientific article

Prospective serial evaluation of 2-hydroxyglutarate, during treatment of newly diagnosed acute myeloid leukemia, to assess disease activity and therapeutic response ⬇️

scientific article published on October 16, 2012

Prospective, high-throughput molecular profiling of human gliomas ⬇️

scientific article published on July 22, 2012

Pulmonary adenocarcinoma mutation profile in smokers with smoking-related interstitial fibrosis

scientific article

ROS1 rearrangements define a unique molecular class of lung cancers

scientific article

Rapid "open-source" engineering of customized zinc-finger nucleases for highly efficient gene modification

scientific article

Rapid Radiographic and Clinical Improvement After Treatment of a MET-Amplified Recurrent Glioblastoma With a Mesenchymal-Epithelial Transition Inhibitor ⬇️

scientific article published on December 12, 2011

Rapid targeted mutational analysis of human tumours: a clinical platform to guide personalized cancer medicine

scientific article published on May 2010

Recurrent Chromosomal Copy Number Alterations in Sporadic Chordomas ⬇️

scientific article published on May 13, 2011

Resensitization to Crizotinib by the Lorlatinib ALK Resistance Mutation L1198F.

scientific article

Routine multiplex mutational profiling of melanomas enables enrollment in genotype-driven therapeutic trials

scientific article (publication date: 2012)

Spectrum of Oncogenic Driver Mutations in Lung Adenocarcinomas from East Asian Never Smokers ⬇️

scientific article published on November 30, 2011

Standardized decision support in next generation sequencing reports of somatic cancer variants

scientific article published on 04 April 2014

Targetable signaling pathway mutations are associated with malignant phenotype in IDH-mutant gliomas.

scientific article

The challenges posed by cancer heterogeneity ⬇️

scientific article (publication date: 10 July 2012)

The dichotomy in carcinogenesis of the distal esophagus and esophagogastric junction: intestinal-type vs cardiac-type mucosa-associated adenocarcinoma.

scientific article published on 13 May 2011

Tumor islands in resected early-stage lung adenocarcinomas are associated with unique clinicopathologic and molecular characteristics and worse prognosis

scientific article published on February 2013

Two novel ALK mutations mediate acquired resistance to the next-generation ALK inhibitor alectinib

scientific article

Unique clinicopathologic features characterize ALK-rearranged lung adenocarcinoma in the western population

scientific article

Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs

scientific article

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