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List of works by Takashi Kojima

A 3-Year Overall Survival Update From a Phase 2 Study of Chemoselection With DCF and Subsequent Conversion Surgery for Locally Advanced Unresectable Esophageal Cancer

scientific article published on 02 August 2019

A Phase I study of intravenous PI3K inhibitor copanlisib in Japanese patients with advanced or refractory solid tumors

scientific article published on 03 December 2016

A Phase III study of oral steroid administration versus local steroid injection therapy for the prevention of esophageal stricture after endoscopic submucosal dissection (JCOG1217, Steroid EESD P3).

scientific article published on 5 August 2015

A laterally-spreading tumor in a colonic interposition treated by endoscopic submucosal dissection

scientific article

A management of neutropenia using granulocyte colony stimulating factor support for chemotherapy consisted of docetaxel, cisplatin and 5-fluorouracil in patients with oesophageal squamous cell carcinoma

scientific article published on 05 November 2020

A phase I dose-escalation study of LY2875358, a bivalent MET antibody, given as monotherapy or in combination with erlotinib or gefitinib in Japanese patients with advanced malignancies

scientific article published on September 2016

A phase I study evaluating cixutumumab, a type 1 insulin-like growth factor receptor inhibitor, given every 2 or 3 weeks in Japanese patients with advanced solid tumors

scientific article published on 30 April 2016

A prospective, multicenter phase I/II study of induction chemotherapy with docetaxel, cisplatin and fluorouracil (DCF) followed by chemoradiotherapy in patients with unresectable locally advanced esophageal carcinoma.

scientific article published on 18 May 2016

A retrospective observational study of clinicopathological features of KRAS, NRAS, BRAF and PIK3CA mutations in Japanese patients with metastatic colorectal cancer

scientific article

A retrospective study of definitive chemoradiotherapy for elderly patients with esophageal cancer

scientific article

A retrospective study of the safety and efficacy of paclitaxel plus ramucirumab in patients with advanced or recurrent gastric cancer with ascites

scientific article published on 31 January 2018

ABCB1 and ABCC2 genetic polymorphism as risk factors for neutropenia in esophageal cancer patients treated with docetaxel, cisplatin, and 5-fluorouracil chemotherapy

scientific article published on 03 August 2020

Activity of S-1 in advanced or recurrent gastric cancer patients after failure of prior chemotherapy, including irinotecan + cisplatin or fluorouracil (except S-1).

scientific article published on 24 March 2009

CD24 and CK4 are upregulated by SIM2, and are predictive biomarkers for chemoradiotherapy and surgery in esophageal cancer

scientific article published on 17 January 2020

Clinical and molecular factors for selection of nivolumab or irinotecan as third-line treatment for advanced gastric cancer

scientific article published on 17 July 2020

Clinical outcome after endoscopic resection for superficial pharyngeal squamous cell carcinoma invading the subepithelial layer

scientific article

Clinical outcomes according to the modified endoscopic criteria for neoadjuvant chemotherapy in resectable esophageal squamous cell carcinoma

scientific article published on 01 August 2019

Clinical outcomes in 66 patients with advanced gastric cancer treated in phase I trials: the NCCHE experience

scientific article published on 15 March 2015

Clinical outcomes of patients with gastrointestinal stromal tumor in phase I clinical trials

scientific article

Clinicopathological and molecular features of responders to nivolumab for patients with advanced gastric cancer

scholarly article by Saori Mishima et al published 31 January 2019 in Journal for Immunotherapy of Cancer

Clinicopathological features of 22C3 PD-L1 expression with mismatch repair, Epstein-Barr virus status, and cancer genome alterations in metastatic gastric cancer.

scientific article

Clinicopathological features of PD-L1 expression with MMR, EBV status and cancer genome alterations in MGC

scientific article published on 01 October 2017

Comprehensive immunohistochemical analysis of tumor microenvironment immune status in esophageal squamous cell carcinoma

scientific article published on 15 June 2016

Concordance between PIK3CA mutations in endoscopic biopsy and surgically resected specimens of esophageal squamous cell carcinoma

scientific article

Depletion of central memory CD8<sup>+</sup> T cells might impede the antitumor therapeutic effect of Mogamulizumab

scientific article published on 14 December 2021

Detection and preliminary evaluation of circulating tumor cells in the peripheral blood of patients with eight types of cancer using a telomerase-specific adenovirus

scientific article

Dosimetric comparison between proton beam therapy and photon radiation therapy for locally advanced esophageal squamous cell carcinoma.

scientific article published on 9 February 2018

ECTAS: A phase II study of TAS-102 for advanced/recurrent esophageal cancer refractory/intolerable to standard therapies

scientific article published on 01 October 2017

Early clinical outcomes of anal squamous cell carcinoma treated with concurrent chemoradiotherapy with 5-Fluorouracil plus mitomycin C in Japanese patients: experience at a single institution

scientific article published on 19 June 2012

Effect of RECIST revision on classification of target lesions and overall response in advanced gastric cancer patients.

scientific article published on 22 August 2012

Effect of food on the pharmacokinetics of TAS-102 and its efficacy and safety in patients with advanced solid tumors

scientific article published on 26 February 2016

Efficacy and Safety of Pembrolizumab for Heavily Pretreated Patients With Advanced, Metastatic Adenocarcinoma or Squamous Cell Carcinoma of the Esophagus: The Phase 2 KEYNOTE-180 Study

scientific article published on 01 April 2019

Efficacy and safety of ramucirumab-containing chemotherapy in patients with pretreated metastatic gastric neuroendocrine carcinoma

scientific article published on 01 November 2018

Efficacy of concurrent chemoradiotherapy as a palliative treatment in stage IVB esophageal cancer patients with dysphagia

scientific article published on 07 July 2011

Efficacy of sequential methotrexate and 5-fluorouracil (MTX/5FU) in improving oral intake in patients with advanced gastric cancer with severe peritoneal dissemination

scientific article published on 5 November 2009

Endoscopic balloon dilatation for benign fibrotic strictures after curative nonsurgical treatment for esophageal cancer

scientific article published on 28 April 2012

Enhanced tumor response to radiotherapy after PD-1 blockade in metastatic gastric cancer

scientific article published on 16 March 2020

Esophageal stenosis and the Glasgow Prognostic Score as independent factors of poor prognosis for patients with locally advanced unresectable esophageal cancer treated with chemoradiotherapy (exploratory analysis of JCOG0303).

scientific article published on 17 July 2017

Evaluation of complications related to therapeutic colonoscopy using the bipolar snare

scientific article published on 23 September 2011

Feasibility of oxaliplatin and infusional fluorouracil/leucovorin (FOLFOX4) for Japanese patients with unresectable metastatic colorectal cancer

scientific article published in June 2007

Feasibility study of nivolumab as neoadjuvant chemotherapy for locally esophageal carcinoma: FRONTiER (JCOG1804E)

scientific article published on 12 May 2020

Gastrointestinal Perforation and Fistula Formation in 5 Patients With Colorectal Cancer During Treatment With Regorafenib.

scientific article

Heat shock protein 105 peptide vaccine could induce antitumor immune reactions in a phase I clinical trial

scientific article published on 19 September 2019

Identification of serum biomarkers of chemoradiosensitivity in esophageal cancer via the targeted metabolomics approach

scientific article published on 25 July 2018

Immunotherapy for Esophageal Squamous Cell Carcinoma

scientific article published on May 2017

Impact of pathologically assessing extranodal extension in the thoracic field on the prognosis of esophageal squamous cell carcinoma

scientific article published on 06 March 2019

Impacts of the STING-IFNAR1-STAT1-IRF1 pathway on the cellular immune reaction induced by fractionated irradiation

scientific article published on 20 February 2022

Improved efficacy of taxanes and ramucirumab combination chemotherapy after exposure to anti-PD-1 therapy in advanced gastric cancer

scientific article published on 01 July 2020

Irinotecan plus cisplatin therapy and S-1 plus cisplatin therapy for advanced or recurrent gastric cancer in a single institution

scientific article

KEYNOTE-590: Phase III study of first-line chemotherapy with or without pembrolizumab for advanced esophageal cancer

scientific article published on 08 February 2019

Large-scale analyses of tumor mutation burdens (TMBs) across various advanced gastrointestinal (GI) malignancies in the nationwide cancer genome screening project, SCRUM-Japan GI-SCREEN

Large-scale comprehensive immunohistochemical biomarker analyses in esophageal squamous cell carcinoma

scientific article published on 29 July 2017

Leucine-Rich Alpha-2-Glycoprotein 1 in Serum Is a Possible Biomarker to Predict Response to Preoperative Chemoradiotherapy for Esophageal Cancer

scientific article published on 01 January 2019

Local efficacy and survival outcome of salvage endoscopic therapy for local recurrent lesions after definitive chemoradiotherapy for esophageal cancer

scientific article published on 27 February 2016

Long-term Clinical Results of Concurrent Chemoradiotherapy for Patients with Cervical Esophageal Squamous Cell Carcinoma

scientific article published on 01 September 2017

Long-term efficacy and predictive correlates of response to nivolumab in Japanese patients with esophageal cancer

scientific article published on 11 March 2020

Long-term outcomes of patients with metastatic gastric cancer after initial S-1 monotherapy

scientific article published on 25 July 2007

Metabolomics-based Discovery of Serum Biomarkers to Predict the Side-effects of Neoadjuvant Chemoradiotherapy for Esophageal Squamous Cell Carcinoma

scientific article published on 01 January 2019

Moderate renal dysfunction may not require a cisplatin dose reduction: a retrospective study of cancer patients with renal impairment ⬇️

scientific article published on 05 October 2012

Morphological change of a laterally spreading rectal tumor over a short period ⬇️

scientific article published on August 19, 2013

Multicenter Phase 2 Study of Cisplatin and 5-Fluorouracil With Concurrent Radiation Therapy as an Organ Preservation Approach in Patients With Squamous Cell Carcinoma of the Cervical Esophagus

scientific article

Neoadjuvant Therapy in Multimodal Surgical Treatment for Squamous Cell Carcinoma of the Esophagus

scientific article published in October 2016

Nivolumab treatment for oesophageal squamous-cell carcinoma: an open-label, multicentre, phase 2 trial

scientific article published on 14 March 2017

Nutrition Support for Head and Neck Squamous Cell Carcinoma Patients Treated with Chemoradiotherapy: How Often and How Long? ⬇️

scientific article published on February 13, 2012

Pathological tumor regression grade of metastatic tumors in lymph node predicts prognosis in esophageal cancer patients.

scientific article published on 30 March 2018

Phase 1 study of napabucasin, a cancer stemness inhibitor, in patients with advanced solid tumors

scientific article published on 31 March 2020

Phase I dose-escalation trial of Sym004, an anti-EGFR antibody mixture, in Japanese patients with advanced solid tumors

Phase I study of docetaxel, cisplatin and S-1 in patients with advanced gastric cancer

scientific article published on 5 July 2010

Phase I/II trial of 2-weekly docetaxel combined with cisplatin plus fluorouracil in metastatic esophageal cancer (JCOG0807).

scientific article published on September 2014

Phase II feasibility study of preoperative concurrent chemoradiotherapy with cisplatin plus 5-fluorouracil and elective lymph node irradiation for clinical stage II/III esophageal squamous cell carcinoma

scientific article published on 14 August 2018

Phase II study of chemoselection with docetaxel plus cisplatin and 5-fluorouracil induction chemotherapy and subsequent conversion surgery for locally advanced unresectable oesophageal cancer

scientific article

Phase Ia Study of FoxP3+ CD4 Treg Depletion by Infusion of a Humanized Anti-CCR4 Antibody, KW-0761, in Cancer Patients

scientific article published in October 2015

Photodynamic therapy as salvage treatment for local failure after chemoradiotherapy in patients with esophageal squamous cell carcinoma: a phase II study.

scientific article

Postoperative pulmonary complications and thoracocentesis associated with early versus late chest tube removal after thoracic esophagectomy with three-field dissection: a propensity score matching analysis

scientific article published on 17 July 2018

Preclinical efficacy of Sym004, novel anti-EGFR antibody mixture, in esophageal squamous cell carcinoma cell lines.

scientific article published on 26 December 2016

Predictive factors for hyperprogressive disease during nivolumab as anti-PD1 treatment in patients with advanced gastric cancer

scientific article published on 09 January 2019

Prognostic significance of tumor regression grade for patients with esophageal squamous cell carcinoma after neoadjuvant chemotherapy followed by surgery

scientific article

Prophylactic Use of Oral Dexamethasone to Alleviate Fatigue During Regorafenib Treatment for Patients With Metastatic Colorectal Cancer

scientific article published on 18 August 2016

Pulmonary tumor thrombotic microangiopathy associated with esophageal squamous cell carcinoma

scientific article

Randomized Phase III KEYNOTE-181 Study of Pembrolizumab Versus Chemotherapy in Advanced Esophageal Cancer

scientific article published on 07 October 2020

Regorafenib Plus Nivolumab in Patients With Advanced Gastric or Colorectal Cancer: An Open-Label, Dose-Escalation, and Dose-Expansion Phase Ib Trial (REGONIVO, EPOC1603)

scientific article published on 28 April 2020

Relationship between the immune microenvironment of different locations in a primary tumour and clinical outcomes of oesophageal squamous cell carcinoma

scientific article published on 25 November 2019

Retrospective analysis of S-1 monotherapy in patients with metastatic colorectal cancer after failure to fluoropyrimidine and irinotecan or to fluoropyrimidine, irinotecan and oxaliplatin.

scientific article published in May 2009

Retrospective cohort study of trifluridine/tipiracil (TAS-102) plus bevacizumab versus trifluridine/tipiracil monotherapy for metastatic colorectal cancer

scientific article published on 27 December 2019

Review of early endoscopic findings in patients with local recurrence after definitive chemoradiotherapy for esophageal squamous cell carcinoma

scientific article published on 30 March 2020

Risk factors for febrile neutropenia in neoadjuvant docetaxel, cisplatin, and 5-fluorouracil chemotherapy for esophageal cancer

scientific article published on 24 July 2019

Safety and Efficacy of Trifluridine/Tipiracil Monotherapy in Clinical Practice for Patients With Metastatic Colorectal Cancer: Experience at a Single Institution

scientific article published on 27 November 2015

Safety of bevacizumab treatment in combination with standard chemotherapy for metastatic colorectal cancer: a retrospective review of 65 Japanese patients

scientific article published on 05 December 2009

Salvage endoscopic resection (ER) after chemoradiotherapy for esophageal squamous cell carcinoma: What are the risk factors for recurrence after salvage ER?

scientific article published on 6 November 2017

Salvage photodynamic therapy for local failure after chemoradiotherapy for esophageal squamous cell carcinoma

scientific article published on 19 November 2015

Soluble interleukin‐6 receptor is a serum biomarker for the response of esophageal carcinoma to neoadjuvant chemoradiotherapy ⬇️

scientific article published on June 13, 2013

TENERGY: multicenter phase II study of Atezolizumab monotherapy following definitive Chemoradiotherapy with 5-FU plus Cisplatin in patients with unresectable locally advanced esophageal squamous cell carcinoma

scientific article published on 20 April 2020

TS gene tandem repeats in esophageal cancer patients receiving chemoradiotherapy ⬇️

scientific article published on January 1, 2011

The Nationwide Cancer Genome Screening Project in Japan, SCRUM-Japan GI-screen: Efficient identification of cancer genome alterations in advanced esophageal cancer

The impact of molecular subtype on efficacy of chemotherapy and checkpoint inhibition in advanced gastric cancer

scientific article published on 10 March 2020

The prognostic significance of the positive circumferential resection margin in pathologic T3 squamous cell carcinoma of the esophagus with or without neoadjuvant chemotherapy

scientific article published on 18 September 2015

Therapeutic results of proton beam therapy with concurrent chemotherapy for cT1 esophageal cancer and salvage endoscopic therapy for local recurrence

scientific article published on 21 January 2020

Therapeutic significance of a D-dimer cut-off level of >3 µg/ml in colorectal cancer patients treated with standard chemotherapy plus bevacizumab

scientific article published on 21 May 2010

Thoracoscopic esophagectomy with three-field lymphadenectomy for thoracic esophageal cancer in a patient with a double aortic arch: a report of a case.

scientific article published on 16 May 2019

Treatment strategy for superficial pharyngeal squamous cell carcinoma synchronously combined with esophageal cancer

scientific article published on 30 October 2012

U3-1402, a Novel HER3-Targeting Antibody-Drug Conjugate, for the Treatment of Colorectal Cancer

scientific article published on 08 August 2019

Unexpected endoscopic full-thickness resection of a duodenal neuroendocrine tumor

scientific article published on July 2013

Weekly Paclitaxel after failure of gemcitabine in pancreatic cancer patients with malignant ascites: a retrospective study

scientific article published on 22 July 2010

Weekly paclitaxel for heavily treated advanced or recurrent gastric cancer refractory to fluorouracil, irinotecan, and cisplatin

scientific article

[Chemoradiotherapy]

scientific article published on 01 August 2011

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