List of works - Winand N M Dinjens

A metastasis of an adenocarcinoma in a BRCA1 mutation carrier, a diagnostic problem not solved by morphology alone

scientific article

A mononucleotide repeat in PRRT2 is an important, frequent target of mismatch repair deficiency in cancer.

scientific article

A review on the molecular diagnostics of Lynch syndrome: a central role for the pathology laboratory

scientific article

A subset of head and neck squamous cell carcinomas exhibits integration of HPV 16/18 DNA and overexpression of p16INK4A and p53 in the absence of mutations in p53 exons 5–8 ⬇️

scientific article published on November 10, 2003

Adjuvant procarbazine, lomustine, and vincristine chemotherapy in newly diagnosed anaplastic oligodendroglioma: long-term follow-up of EORTC brain tumor group study 26951.

scientific article

Adrenal medullary hyperplasia is a precursor lesion for pheochromocytoma in MEN2 syndrome

scientific article published on 23 October 2014

An International Ki67 Reproducibility Study in Adrenal Cortical Carcinoma.

scientific article published on 17 December 2015

An immunohistochemical procedure to detect patients with paraganglioma and phaeochromocytoma with germline SDHB, SDHC, or SDHD gene mutations: a retrospective and prospective analysis

scientific article

Anisometric Cell and Dysplastic Lipomas in a Retinoblastoma Patient

scientific article published on 04 May 2020

Array-comparative genomic hybridization in sporadic benign pheochromocytomas

scientific article published on 19 January 2009

Barrett's oesophageal adenocarcinoma encompasses tumour-initiating cells that do not express common cancer stem cell markers

scientific article published on August 2010

Candidate gene mutation analysis in bilateral adrenal pheochromocytoma and sympathetic paraganglioma.

scientific article published in June 2007

Chemotherapy followed by surgery versus surgery alone in patients with resectable oesophageal squamous cell carcinoma: long-term results of a randomized controlled trial

scientific article

Chromosomal anomalies in oligodendroglial tumors are correlated with clinical features.

scientific article published in March 2003

Clinical Aspects of SDHA-Related Pheochromocytoma and Paraganglioma: A Nationwide Study.

scientific article published on 21 November 2017

Clinical characteristics of pheochromocytoma patients with germline mutations in SDHD.

scientific article

Clinical importance of molecular determinations in gynecologic patients with multiple tumors

scientific article published on 01 April 2003

Complex MAX Rearrangement in a Family With Malignant Pheochromocytoma, Renal Oncocytoma, and Erythrocytosis.

scientific article published on 15 December 2015

Conditional Pten knock-out mice: a model for metastatic phaeochromocytoma

scientific article published in March 2009

Construction and application of a full-coverage, high-resolution, human chromosome 8q genomic microarray for comparative genomic hybridization

scientific article published on January 2005

Correction: Functional Ex Vivo Assay Reveals Homologous Recombination Deficiency in Breast Cancer Beyond BRCA Gene Defects

scientific article published on 01 May 2019

Defects in succinate dehydrogenase in gastrointestinal stromal tumors lacking KIT and PDGFRA mutations

scientific article

Detection of spontaneous tumorigenic transformation during culture expansion of human mesenchymal stromal cells.

scientific article published on 13 November 2013

Determination of the molecular relationship between multiple tumors within one patient is of clinical importance

scientific article published in February 2002

Double somatic mutations in mismatch repair genes are frequent in colorectal cancer after Hodgkin's lymphoma treatment

scientific article published on 8 November 2016

EGFR and KRAS quality assurance schemes in pathology: generating normative data for molecular predictive marker analysis in targeted therapy.

scientific article

Early onset esophageal adenocarcinoma: a distinct molecular entity?

scientific article published on February 2016

Expression of Contactin 4 Is Associated With Malignant Behavior in Pheochromocytomas and Paragangliomas

scientific article published on 17 August 2017

Expression of the bile acid receptor FXR in Barrett's esophagus and enhancement of apoptosis by guggulsterone in vitro.

scientific article

First-line temozolomide chemotherapy in progressive low-grade astrocytomas after radiotherapy: molecular characteristics in relation to response

scientific article

Frequent genetic changes in childhood pheochromocytomas

scientific article published on 01 August 2006

Frequent germ-line succinate dehydrogenase subunit D gene mutations in patients with apparently sporadic parasympathetic paraganglioma.

scientific article

Frequent loss of 17p, but no p53 mutations or protein overexpression in benign and malignant pheochromocytomas.

scientific article

Functional Assay Reveals Homologous Recombination Deficiency in Breast Cancer Beyond BRCA Gene Defects

article

Functional Polymorphisms Associated with Disease-Free Survival in Resected Carcinoma of the Esophagus ⬇️

scientific article published on October 5, 2010

H-RAS mutations are restricted to sporadic pheochromocytomas lacking specific clinical or pathological features: data from a multi-institutional series.

scientific article

Hereditary Factors in Esophageal Adenocarcinoma

scientific article published on 09 May 2014

IDH1 and IDH2 mutations are prognostic but not predictive for outcome in anaplastic oligodendroglial tumors: a report of the European Organization for Research and Treatment of Cancer Brain Tumor Group

scientific article

IL-7 Receptor Mutations and Steroid Resistance in Pediatric T cell Acute Lymphoblastic Leukemia: A Genome Sequencing Study

scientific article

Identification of Mutations in Cell-Free Circulating Tumor DNA in Adrenocortical Carcinoma: A Case Series

scientific article published on 30 June 2017

Identification of a 7.1-mega base pairs minimal deletion at 14q31.1-32.11 in adenocarcinomas of the gastroesophageal junction

scientific article published on 20 March 2006

Intra-tumoral molecular heterogeneity in benign and malignant pheochromocytomas and extra-adrenal sympathetic paragangliomas

scientific article published on 25 June 2010

Isocitrate dehydrogenase mutations are rare in pheochromocytomas and paragangliomas.

scientific article

Loss of Y-Chromosome during Male Breast Carcinogenesis

scientific article published on 09 March 2020

MGMT promoter hypermethylation is a frequent, early, and consistent event in astrocytoma progression, and not correlated with TP53 mutation.

scientific article

MGMT promoter methylation is prognostic but not predictive for outcome to adjuvant PCV chemotherapy in anaplastic oligodendroglial tumors: a report from EORTC Brain Tumor Group Study 26951.

scientific article

Mapping of homozygous deletions in verified esophageal adenocarcinoma cell lines and xenografts

scientific article

Microarray-based CGH of sporadic and syndrome-related pheochromocytomas using a 0.1-0.2 Mb bacterial artificial chromosome array spanning chromosome arm 1p

scientific article published on 01 January 2006

Microsatellite instability of germ cell tumors is associated with resistance to systemic treatment.

scientific article published in May 2002

Mismatch repair and treatment resistance in ovarian cancer

scientific article

Mistaken identity of widely used esophageal adenocarcinoma cell line TE-7.

scientific article published on September 2007

Molecular biological challenges in he treatment of esophageal adenocarcinoma

scientific article published on December 2007

Molecular classification of anaplastic oligodendroglioma using next-generation sequencing: a report of the prospective randomized EORTC Brain Tumor Group 26951 phase III trial.

scientific article published on 9 September 2015

Molecular clonality analysis of esophageal adenocarcinoma by multiregion sequencing of tumor samples

scientific article

Molecular genetic alterations in adrenal and extra-adrenal pheochromocytomas and paragangliomas

scientific article published on January 2003

Mutation of SDHB is a cause of hypoxia-related high-altitude paraganglioma

scientific article

New developments in the detection of the clinical behavior of pheochromocytomas and paragangliomas

scientific article published on January 2006

Next generation diagnostic molecular pathology: critical appraisal of quality assurance in Europe.

scientific article published on 18 March 2014

Non-pheochromocytoma (PCC)/paraganglioma (PGL) tumors in patients with succinate dehydrogenase-related PCC-PGL syndromes: a clinicopathological and molecular analysis.

scientific article published on 22 November 2013

PIK3CA mutations in ductal carcinoma in situ and adjacent invasive breast cancer

scientific article published on 01 May 2019

Paraganglioma and pheochromocytoma upon maternal transmission of SDHD mutations

scientific article

Parasympathetic paragangliomas are part of the Von Hippel-Lindau syndrome.

scientific article published on 6 October 2009

Prevalence of c-KIT mutations in gonadoblastoma and dysgerminomas of patients with disorders of sex development (DSD) and ovarian dysgerminomas

scientific article

SDHA Immunohistochemistry Detects GermlineSDHAGene Mutations in Apparently Sporadic Paragangliomas and Pheochromocytomas

scientific article published on 13 July 2011

SDHA mutations in adult and pediatric wild-type gastrointestinal stromal tumors

scientific article published on 23 November 2012

SDHAF2 mutations in familial and sporadic paraganglioma and phaeochromocytoma

scientific article

SDHB immunohistochemistry: a useful tool in the diagnosis of Carney-Stratakis and Carney triad gastrointestinal stromal tumors

scientific article

SDHB/SDHA immunohistochemistry in pheochromocytomas and paragangliomas: a multicenter interobserver variation analysis using virtual microscopy: a Multinational Study of the European Network for the Study of Adrenal Tumors (ENS@T).

scientific article published on 27 February 2015

Sarcoma classification by DNA methylation profiling

scientific article published on 21 January 2021

Sarcomatoid adrenocortical carcinoma: a comprehensive pathological, immunohistochemical, and targeted next-generation sequencing analysis.

scientific article published on 30 August 2016

Single nucleotide polymorphisms in CRTC1 and BARX1 are associated with esophageal adenocarcinoma

scientific article published on 21 May 2015

Single-agent bevacizumab or lomustine versus a combination of bevacizumab plus lomustine in patients with recurrent glioblastoma (BELOB trial): a randomised controlled phase 2 trial.

scientific article

Somatic SDHB mutation in an extraadrenal pheochromocytoma

scientific article published on 01 July 2007

Somatic aberrations of mismatch repair genes as a cause of microsatellite-unstable cancers

scientific article published on 30 September 2014

Somatic mutations and copy number variations in breast cancers with heterogeneous HER2 amplification

scientific article published on 14 February 2020

Succinate Dehydrogenase (SDH)-Deficient Pancreatic Neuroendocrine Tumor Expands the SDH-Related Tumor Spectrum.

scientific article published on 10 August 2015

Telomerase reverse transcriptase promoter mutations in tumors originating from the adrenal gland and extra-adrenal paraganglia

scientific article

The Pathogenesis of Barrett’s Metaplasia and the Progression to Esophageal Adenocarcinoma ⬇️

scientific article published on January 1, 2010

The clonal relation of primary upper urinary tract urothelial carcinoma and paired urothelial carcinoma of the bladder

scientific article published on 02 October 2020

The molecular biology of esophageal adenocarcinoma.

scientific article

The occurrence of SDHB gene mutations in pheochromocytoma

scientific article published on August 2006

Three-gene immunohistochemical panel adds to clinical staging algorithms to predict prognosis for patients with esophageal adenocarcinoma

scientific article published on 18 March 2013

Tissue inhibitor of metalloproteinase-3 (TIMP3) expression decreases during melanoma progression and inhibits melanoma cell migration

scientific article published on 11 August 2016

Toward an improved definition of the genetic and tumor spectrum associated with SDH germ-line mutations.

scientific article

Trp53 inactivation leads to earlier phaeochromocytoma formation in pten knockout mice

scientific article published on 30 October 2012

Vascular pattern analysis for the prediction of clinical behaviour in pheochromocytomas and paragangliomas

scientific article

Verification and unmasking of widely used human esophageal adenocarcinoma cell lines.

scientific article

Von Hippel-Lindau gene alterations in sporadic benign and malignant pheochromocytomas

scientific article published on 01 June 2003

p53 alterations and their relationship to SDHD mutations in parasympathetic paragangliomas

scientific article published in September 2003

List of works by Winand N M Dinjens

A metastasis of an adenocarcinoma in a BRCA1 mutation carrier, a diagnostic problem not solved by morphology alone

A mononucleotide repeat in PRRT2 is an important, frequent target of mismatch repair deficiency in cancer.

A review on the molecular diagnostics of Lynch syndrome: a central role for the pathology laboratory

A subset of head and neck squamous cell carcinomas exhibits integration of HPV 16/18 DNA and overexpression of p16INK4A and p53 in the absence of mutations in p53 exons 5–8 ⬇️

Adjuvant procarbazine, lomustine, and vincristine chemotherapy in newly diagnosed anaplastic oligodendroglioma: long-term follow-up of EORTC brain tumor group study 26951.

Adrenal medullary hyperplasia is a precursor lesion for pheochromocytoma in MEN2 syndrome

An International Ki67 Reproducibility Study in Adrenal Cortical Carcinoma.

An immunohistochemical procedure to detect patients with paraganglioma and phaeochromocytoma with germline SDHB, SDHC, or SDHD gene mutations: a retrospective and prospective analysis

Anisometric Cell and Dysplastic Lipomas in a Retinoblastoma Patient

Array-comparative genomic hybridization in sporadic benign pheochromocytomas

Barrett's oesophageal adenocarcinoma encompasses tumour-initiating cells that do not express common cancer stem cell markers

Candidate gene mutation analysis in bilateral adrenal pheochromocytoma and sympathetic paraganglioma.

Chemotherapy followed by surgery versus surgery alone in patients with resectable oesophageal squamous cell carcinoma: long-term results of a randomized controlled trial

Chromosomal anomalies in oligodendroglial tumors are correlated with clinical features.

Clinical Aspects of SDHA-Related Pheochromocytoma and Paraganglioma: A Nationwide Study.

Clinical characteristics of pheochromocytoma patients with germline mutations in SDHD.

Clinical importance of molecular determinations in gynecologic patients with multiple tumors

Complex MAX Rearrangement in a Family With Malignant Pheochromocytoma, Renal Oncocytoma, and Erythrocytosis.

Conditional Pten knock-out mice: a model for metastatic phaeochromocytoma

Construction and application of a full-coverage, high-resolution, human chromosome 8q genomic microarray for comparative genomic hybridization

Correction: Functional Ex Vivo Assay Reveals Homologous Recombination Deficiency in Breast Cancer Beyond BRCA Gene Defects

Defects in succinate dehydrogenase in gastrointestinal stromal tumors lacking KIT and PDGFRA mutations

Detection of spontaneous tumorigenic transformation during culture expansion of human mesenchymal stromal cells.

Determination of the molecular relationship between multiple tumors within one patient is of clinical importance

Double somatic mutations in mismatch repair genes are frequent in colorectal cancer after Hodgkin's lymphoma treatment

EGFR and KRAS quality assurance schemes in pathology: generating normative data for molecular predictive marker analysis in targeted therapy.

Early onset esophageal adenocarcinoma: a distinct molecular entity?

Expression of Contactin 4 Is Associated With Malignant Behavior in Pheochromocytomas and Paragangliomas

Expression of the bile acid receptor FXR in Barrett's esophagus and enhancement of apoptosis by guggulsterone in vitro.

First-line temozolomide chemotherapy in progressive low-grade astrocytomas after radiotherapy: molecular characteristics in relation to response

Frequent genetic changes in childhood pheochromocytomas

Frequent germ-line succinate dehydrogenase subunit D gene mutations in patients with apparently sporadic parasympathetic paraganglioma.

Frequent loss of 17p, but no p53 mutations or protein overexpression in benign and malignant pheochromocytomas.

Functional Assay Reveals Homologous Recombination Deficiency in Breast Cancer Beyond BRCA Gene Defects

Functional Polymorphisms Associated with Disease-Free Survival in Resected Carcinoma of the Esophagus ⬇️

H-RAS mutations are restricted to sporadic pheochromocytomas lacking specific clinical or pathological features: data from a multi-institutional series.

Hereditary Factors in Esophageal Adenocarcinoma

IDH1 and IDH2 mutations are prognostic but not predictive for outcome in anaplastic oligodendroglial tumors: a report of the European Organization for Research and Treatment of Cancer Brain Tumor Group

IL-7 Receptor Mutations and Steroid Resistance in Pediatric T cell Acute Lymphoblastic Leukemia: A Genome Sequencing Study

Identification of Mutations in Cell-Free Circulating Tumor DNA in Adrenocortical Carcinoma: A Case Series

Identification of a 7.1-mega base pairs minimal deletion at 14q31.1-32.11 in adenocarcinomas of the gastroesophageal junction

Intra-tumoral molecular heterogeneity in benign and malignant pheochromocytomas and extra-adrenal sympathetic paragangliomas

Isocitrate dehydrogenase mutations are rare in pheochromocytomas and paragangliomas.

Loss of Y-Chromosome during Male Breast Carcinogenesis

MGMT promoter hypermethylation is a frequent, early, and consistent event in astrocytoma progression, and not correlated with TP53 mutation.

MGMT promoter methylation is prognostic but not predictive for outcome to adjuvant PCV chemotherapy in anaplastic oligodendroglial tumors: a report from EORTC Brain Tumor Group Study 26951.

Mapping of homozygous deletions in verified esophageal adenocarcinoma cell lines and xenografts

Microarray-based CGH of sporadic and syndrome-related pheochromocytomas using a 0.1-0.2 Mb bacterial artificial chromosome array spanning chromosome arm 1p

Microsatellite instability of germ cell tumors is associated with resistance to systemic treatment.

Mismatch repair and treatment resistance in ovarian cancer

Mistaken identity of widely used esophageal adenocarcinoma cell line TE-7.

Molecular biological challenges in he treatment of esophageal adenocarcinoma

Molecular classification of anaplastic oligodendroglioma using next-generation sequencing: a report of the prospective randomized EORTC Brain Tumor Group 26951 phase III trial.

Molecular clonality analysis of esophageal adenocarcinoma by multiregion sequencing of tumor samples

Molecular genetic alterations in adrenal and extra-adrenal pheochromocytomas and paragangliomas

Mutation of SDHB is a cause of hypoxia-related high-altitude paraganglioma

New developments in the detection of the clinical behavior of pheochromocytomas and paragangliomas

Next generation diagnostic molecular pathology: critical appraisal of quality assurance in Europe.

Non-pheochromocytoma (PCC)/paraganglioma (PGL) tumors in patients with succinate dehydrogenase-related PCC-PGL syndromes: a clinicopathological and molecular analysis.

PIK3CA mutations in ductal carcinoma in situ and adjacent invasive breast cancer

Paraganglioma and pheochromocytoma upon maternal transmission of SDHD mutations

Parasympathetic paragangliomas are part of the Von Hippel-Lindau syndrome.

Prevalence of c-KIT mutations in gonadoblastoma and dysgerminomas of patients with disorders of sex development (DSD) and ovarian dysgerminomas

SDHA Immunohistochemistry Detects GermlineSDHAGene Mutations in Apparently Sporadic Paragangliomas and Pheochromocytomas

SDHA mutations in adult and pediatric wild-type gastrointestinal stromal tumors

SDHAF2 mutations in familial and sporadic paraganglioma and phaeochromocytoma

SDHB immunohistochemistry: a useful tool in the diagnosis of Carney-Stratakis and Carney triad gastrointestinal stromal tumors

SDHB/SDHA immunohistochemistry in pheochromocytomas and paragangliomas: a multicenter interobserver variation analysis using virtual microscopy: a Multinational Study of the European Network for the Study of Adrenal Tumors (ENS@T).

Sarcoma classification by DNA methylation profiling

Sarcomatoid adrenocortical carcinoma: a comprehensive pathological, immunohistochemical, and targeted next-generation sequencing analysis.

Single nucleotide polymorphisms in CRTC1 and BARX1 are associated with esophageal adenocarcinoma

Single-agent bevacizumab or lomustine versus a combination of bevacizumab plus lomustine in patients with recurrent glioblastoma (BELOB trial): a randomised controlled phase 2 trial.

Somatic SDHB mutation in an extraadrenal pheochromocytoma

Somatic aberrations of mismatch repair genes as a cause of microsatellite-unstable cancers

Somatic mutations and copy number variations in breast cancers with heterogeneous HER2 amplification

Succinate Dehydrogenase (SDH)-Deficient Pancreatic Neuroendocrine Tumor Expands the SDH-Related Tumor Spectrum.

Telomerase reverse transcriptase promoter mutations in tumors originating from the adrenal gland and extra-adrenal paraganglia

The Pathogenesis of Barrett’s Metaplasia and the Progression to Esophageal Adenocarcinoma ⬇️

The clonal relation of primary upper urinary tract urothelial carcinoma and paired urothelial carcinoma of the bladder