List of works - Alessandra Zingoni

ATM-ATR-dependent up-regulation of DNAM-1 and NKG2D ligands on multiple myeloma cells by therapeutic agents results in enhanced NK-cell susceptibility and is associated with a senescent phenotype

scientific article

Activation of liver X receptor up-regulates the expression of the NKG2D ligands MICA and MICB in multiple myeloma through different molecular mechanisms

scientific article published on 24 May 2019

An optimized retinoic acid-inducible gene I agonist M8 induces immunogenic cell death markers in human cancer cells and dendritic cell activation

scientific article published on 28 August 2019

Antigen-activated human T lymphocytes express cell-surface NKG2D ligands via an ATM/ATR-dependent mechanism and become susceptible to autologous NK- cell lysis

scientific article published on 03 April 2007

Author Correction: Interplay of protein corona and immune cells controls blood residency of liposomes

scientific article published on 31 March 2020

Bone Marrow Stromal Cell-Derived IL-8 Upregulates PVR Expression on Multiple Myeloma Cells via NF-kB Transcription Factor

scientific article published on 13 February 2020

Cancer Exosomes as Conveyors of Stress-Induced Molecules: New Players in the Modulation of NK Cell Response ⬇️

scientific article published on 31 January 2019

Cancer extracellular vesicles as novel regulators of NK cell response

scientific article published on 30 November 2019

Cross-talk between activated human NK cells and CD4+ T cells via OX40-OX40 ligand interactions

scientific journal article

DNAM-1 ligand expression on Ag-stimulated T lymphocytes is mediated by ROS-dependent activation of DNA-damage response: relevance for NK-T cell interaction

scientific article

Detuning CD8+ T lymphocytes by down-regulation of the activating receptor NKG2D: role of NKG2D ligands released by activated T cells

scientific article published on 05 January 2009

Distinct Roles for Human Cytomegalovirus Immediate Early Proteins IE1 and IE2 in the Transcriptional Regulation of MICA and PVR/CD155 Expression.

scientific article published on 12 October 2016

Drug-induced senescent Multiple Myeloma cells elicit NK cell proliferation by direct or exosome-mediated IL-15 trans-presentation.

scientific article published on 24 April 2018

Engagement of NKG2D by cognate ligand or antibody alone is insufficient to mediate costimulation of human and mouse CD8+ T cells.

scientific article published on February 2005

Exosome-delivered microRNAs promote IFN-α secretion by human plasmacytoid DCs via TLR7.

scientific article published on 17 May 2018

Genotoxic Stress Induces Senescence-Associated ADAM10-Dependent Release of NKG2D MIC Ligands in Multiple Myeloma Cells.

scientific article published on 12 June 2015

Genotoxic stress modulates the release of exosomes from multiple myeloma cells capable of activating NK cell cytokine production: Role of HSP70/TLR2/NF-kB axis.

scientific article published on 13 January 2017

HCV-DAA therapy impacts on extracellular vesicles miRNAs content and on their immunomodulating properties

scientific article published on 22 January 2018

High expression levels of IP10/CXCL10 are associated with modulation of the natural killer cell compartment in multiple myeloma.

scientific article

High-efficient lentiviral vector-mediated gene transfer into primary human NK cells

scientific article published on October 2006

Human immunodeficiency virus 1 Nef protein downmodulates the ligands of the activating receptor NKG2D and inhibits natural killer cell-mediated cytotoxicity

scientific article published on January 2007

Human leukocyte antigen E contributes to protect tumor cells from lysis by natural killer cells.

scientific article published on September 2011

Immune complexes exposed on mast cell-derived nanovesicles amplify allergic inflammation

scientific article published on 12 November 2019

Impact of the protein corona on nanomaterial immune response and targeting ability

scientific article published on 30 January 2020

Inhibition of bromodomain and extra-terminal (BET) proteins increases NKG2D ligand MICA expression and sensitivity to NK cell-mediated cytotoxicity in multiple myeloma cells: role of cMYC-IRF4-miR-125b interplay

scientific article published on December 2016

Inhibition of glycogen synthase kinase-3 increases NKG2D ligand MICA expression and sensitivity to NK cell-mediated cytotoxicity in multiple myeloma cells: role of STAT3.

scientific article published on 17 May 2013

Interplay of protein corona and immune cells controls blood residency of liposomes

scientific article published on 15 August 2019

Key Role of the CD56CD16 Natural Killer Cell Subset in the Recognition and Killing of Multiple Myeloma Cells

Large-Scale Profiling of Extracellular Vesicles Identified miR-625-5p as a Novel Biomarker of Immunotherapy Response in Advanced Non-Small-Cell Lung Cancer Patients

scientific article published on 14 May 2022

MICA-129 Dimorphism and Soluble MICA Are Associated With the Progression of Multiple Myeloma.

scientific article published in May 2018

Multiple Myeloma Impairs Bone Marrow Localization of Effector Natural Killer Cells by Altering the Chemokine Microenvironment.

scientific article published on 5 October 2015

NK cell effector functions in a Chédiak-Higashi patient undergoing cord blood transplantation: Effects of in vitro treatment with IL-2.

scientific article published on 2 November 2016

NK cell regulation of T cell-mediated responses.

scientific article

NKG2D Ligand Shedding in Response to Stress: Role of ADAM10

scientific article published on 25 March 2020

NKG2D and DNAM-1 Ligands: Molecular Targets for NK Cell-Mediated Immunotherapeutic Intervention in Multiple Myeloma

scientific article

NKG2D and DNAM-1 activating receptors and their ligands in NK-T cell interactions: role in the NK cell-mediated negative regulation of T cell responses

scientific article published on January 2012

NKG2D and Its Ligands: "One for All, All for One".

scientific article

Natural Killer Cell Response to Chemotherapy-Stressed Cancer Cells: Role in Tumor Immunosurveillance.

scientific article published on 25 September 2017

Natural killer (NK) cells from killers to regulators: distinct features between peripheral blood and decidual NK cells

scientific article published on September 2007

Nitric oxide donors increase PVR/CD155 DNAM-1 ligand expression in multiple myeloma cells: role of DNA damage response activation.

scientific article published on 22 January 2015

Post-translational Mechanisms Regulating NK Cell Activating Receptors and Their Ligands in Cancer: Potential Targets for Therapeutic Intervention

scientific article published on 31 October 2019

Recognition of a carbohydrate xenoepitope by human NKRP1A (CD161)

scientific article

SAMHD1 phosphorylation and cytoplasmic relocalization after human cytomegalovirus infection limits its antiviral activity

scientific article published on 28 September 2020

Senescent cells: Living or dying is a matter of NK cells

scientific article published on 27 February 2019

Src-dependent Syk activation controls CD69-mediated signaling and function on human NK cells.

scientific article

Targeting NKG2D and NKp30 Ligands Shedding to Improve NK Cell-Based Immunotherapy

scientific article published in January 2016

The DNA Damage Response: A Common Pathway in the Regulation of NKG2D and DNAM-1 Ligand Expression in Normal, Infected, and Cancer Cells.

scientific article published on 07 January 2014

The IMiDs targets IKZF-1/3 and IRF4 as novel negative regulators of NK cell-activating ligands expression in multiple myeloma

scientific article

The homeobox transcription factor MEIS2 is a regulator of cancer cell survival and IMiDs activity in Multiple Myeloma: modulation by Bromodomain and Extra-Terminal (BET) protein inhibitors

scientific article published on 11 April 2019

Translating the anti-myeloma activity of Natural Killer cells into clinical application

scientific article published on 10 October 2018

Tumor-associated and immunochemotherapy-dependent long-term alterations of the peripheral blood NK cell compartment in DLBCL patients

scientific article

Tuning the Orchestra: HCMV vs. Innate Immunity

scientific article published on 15 April 2020

c-Cbl regulates MICA- but not ULBP2-induced NKG2D down-modulation in human NK cells.

scientific article

p38 MAPK differentially controls NK activating ligands at transcriptional and post-transcriptional level on multiple myeloma cells.

scientific article published on 2 December 2016

List of works by Alessandra Zingoni

ATM-ATR-dependent up-regulation of DNAM-1 and NKG2D ligands on multiple myeloma cells by therapeutic agents results in enhanced NK-cell susceptibility and is associated with a senescent phenotype

Activation of liver X receptor up-regulates the expression of the NKG2D ligands MICA and MICB in multiple myeloma through different molecular mechanisms

An optimized retinoic acid-inducible gene I agonist M8 induces immunogenic cell death markers in human cancer cells and dendritic cell activation

Antigen-activated human T lymphocytes express cell-surface NKG2D ligands via an ATM/ATR-dependent mechanism and become susceptible to autologous NK- cell lysis

Author Correction: Interplay of protein corona and immune cells controls blood residency of liposomes

Bone Marrow Stromal Cell-Derived IL-8 Upregulates PVR Expression on Multiple Myeloma Cells via NF-kB Transcription Factor

Cancer Exosomes as Conveyors of Stress-Induced Molecules: New Players in the Modulation of NK Cell Response ⬇️

Cancer extracellular vesicles as novel regulators of NK cell response

Cross-talk between activated human NK cells and CD4+ T cells via OX40-OX40 ligand interactions

DNAM-1 ligand expression on Ag-stimulated T lymphocytes is mediated by ROS-dependent activation of DNA-damage response: relevance for NK-T cell interaction

Detuning CD8+ T lymphocytes by down-regulation of the activating receptor NKG2D: role of NKG2D ligands released by activated T cells

Distinct Roles for Human Cytomegalovirus Immediate Early Proteins IE1 and IE2 in the Transcriptional Regulation of MICA and PVR/CD155 Expression.

Drug-induced senescent Multiple Myeloma cells elicit NK cell proliferation by direct or exosome-mediated IL-15 trans-presentation.

Engagement of NKG2D by cognate ligand or antibody alone is insufficient to mediate costimulation of human and mouse CD8+ T cells.

Exosome-delivered microRNAs promote IFN-α secretion by human plasmacytoid DCs via TLR7.

Genotoxic Stress Induces Senescence-Associated ADAM10-Dependent Release of NKG2D MIC Ligands in Multiple Myeloma Cells.

Genotoxic stress modulates the release of exosomes from multiple myeloma cells capable of activating NK cell cytokine production: Role of HSP70/TLR2/NF-kB axis.

HCV-DAA therapy impacts on extracellular vesicles miRNAs content and on their immunomodulating properties

High expression levels of IP10/CXCL10 are associated with modulation of the natural killer cell compartment in multiple myeloma.

High-efficient lentiviral vector-mediated gene transfer into primary human NK cells

Human immunodeficiency virus 1 Nef protein downmodulates the ligands of the activating receptor NKG2D and inhibits natural killer cell-mediated cytotoxicity

Human leukocyte antigen E contributes to protect tumor cells from lysis by natural killer cells.

Immune complexes exposed on mast cell-derived nanovesicles amplify allergic inflammation

Impact of the protein corona on nanomaterial immune response and targeting ability

Inhibition of bromodomain and extra-terminal (BET) proteins increases NKG2D ligand MICA expression and sensitivity to NK cell-mediated cytotoxicity in multiple myeloma cells: role of cMYC-IRF4-miR-125b interplay

Inhibition of glycogen synthase kinase-3 increases NKG2D ligand MICA expression and sensitivity to NK cell-mediated cytotoxicity in multiple myeloma cells: role of STAT3.

Interplay of protein corona and immune cells controls blood residency of liposomes

Key Role of the CD56CD16 Natural Killer Cell Subset in the Recognition and Killing of Multiple Myeloma Cells

Large-Scale Profiling of Extracellular Vesicles Identified miR-625-5p as a Novel Biomarker of Immunotherapy Response in Advanced Non-Small-Cell Lung Cancer Patients

MICA-129 Dimorphism and Soluble MICA Are Associated With the Progression of Multiple Myeloma.

Multiple Myeloma Impairs Bone Marrow Localization of Effector Natural Killer Cells by Altering the Chemokine Microenvironment.

NK cell effector functions in a Chédiak-Higashi patient undergoing cord blood transplantation: Effects of in vitro treatment with IL-2.

NK cell regulation of T cell-mediated responses.

NKG2D Ligand Shedding in Response to Stress: Role of ADAM10

NKG2D and DNAM-1 Ligands: Molecular Targets for NK Cell-Mediated Immunotherapeutic Intervention in Multiple Myeloma

NKG2D and DNAM-1 activating receptors and their ligands in NK-T cell interactions: role in the NK cell-mediated negative regulation of T cell responses

NKG2D and Its Ligands: "One for All, All for One".

Natural Killer Cell Response to Chemotherapy-Stressed Cancer Cells: Role in Tumor Immunosurveillance.

Natural killer (NK) cells from killers to regulators: distinct features between peripheral blood and decidual NK cells

Nitric oxide donors increase PVR/CD155 DNAM-1 ligand expression in multiple myeloma cells: role of DNA damage response activation.

Post-translational Mechanisms Regulating NK Cell Activating Receptors and Their Ligands in Cancer: Potential Targets for Therapeutic Intervention

Recognition of a carbohydrate xenoepitope by human NKRP1A (CD161)

SAMHD1 phosphorylation and cytoplasmic relocalization after human cytomegalovirus infection limits its antiviral activity

Senescent cells: Living or dying is a matter of NK cells

Src-dependent Syk activation controls CD69-mediated signaling and function on human NK cells.

Targeting NKG2D and NKp30 Ligands Shedding to Improve NK Cell-Based Immunotherapy

The DNA Damage Response: A Common Pathway in the Regulation of NKG2D and DNAM-1 Ligand Expression in Normal, Infected, and Cancer Cells.

The IMiDs targets IKZF-1/3 and IRF4 as novel negative regulators of NK cell-activating ligands expression in multiple myeloma

The homeobox transcription factor MEIS2 is a regulator of cancer cell survival and IMiDs activity in Multiple Myeloma: modulation by Bromodomain and Extra-Terminal (BET) protein inhibitors

Translating the anti-myeloma activity of Natural Killer cells into clinical application

Tumor-associated and immunochemotherapy-dependent long-term alterations of the peripheral blood NK cell compartment in DLBCL patients

Tuning the Orchestra: HCMV vs. Innate Immunity

c-Cbl regulates MICA- but not ULBP2-induced NKG2D down-modulation in human NK cells.

p38 MAPK differentially controls NK activating ligands at transcriptional and post-transcriptional level on multiple myeloma cells.