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The PPARβ/δ activator GW501516 prevents the down-regulation of AMPK caused by a high-fat diet in liver and amplifies the PGC-1α-Lipin 1-PPARα pathway leading to increased fatty acid oxidation.

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Description scientific article
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author: Jesús Balsinde  Ricardo Rodríguez-Calvo  Emma Barroso 

Publication date March 1, 2011
Language English
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