The gatekeeper mutation T315I confers resistance against small molecules by increasing or restoring the ABL-kinase activity accompanied by aberrant transphosphorylation of endogenous BCR, even in loss-of-function mutants of BCR/ABL.
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| Description | scientific article published on 16 April 2009 |
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author: Oliver Ottmann Martin Ruthardt Afsar Mian |
| Publication date | April 16, 2009 |
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