In mouse embryonic fibroblasts, neither caspase-8 nor cellular FLICE-inhibitory protein (FLIP) is necessary for TNF to activate NF-κB, but caspase-8 is required for TNF to cause cell death, and induction of FLIP by NF-κB is required to prevent it.
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| Description | scientific article |
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author: Afsar U Ahmed David L Vaux |
| Publication date | November 18, 2011 |
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