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Germline missense pathogenic variants in the BRCA1 BRCT domain, p.Gly1706Glu and p.Ala1708Glu, increase cellular sensitivity to PARP inhibitor olaparib by a dominant negative effect.

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Description scientific article published on 13 October 2016
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author: Javier Benitez  Diego Megías  Alvaro Monteiro  Sergio Gomez-Lopez  Manel Esteller  Ana Osorio 

Publication date December 1, 2016
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